Pulmonary long-term consequences of COVID-19 infections after hospital discharge

Blanco, J.R. ; Cobos-Ceballos, M.J. ; Navarro, F. ; Sanjoaquin, I. (Universidad de Zaragoza) ; Arnaiz de las Revillas, F. ; Bernal, E. ; Buzon-Martin, L. ; Viribay, M. ; Romero, L. ; Espejo-Pérez, S. ; Valencia, B. ; Ibañez, D. (Universidad de Zaragoza) ; Ferrer-Pargada, D. ; Malia, D. ; Gutierrez-Herrero, F.G. ; Olalla, J. ; Jurado-Gamez, B. ; Ugedo, J.

Resumen: Objectives: COVID-19 survivors are reporting residual abnormalities after discharge from the hospital. Limited information is available about this stage of recovery or the lingering effects of the virus on pulmonary function and inflammation. The aim of this study was to describe lung function and to identify biomarkers in serum and induced sputum samples from patients recovering from COVID-19 hospitalisation.

Methods: Patients admitted to Spanish hospitals with laboratory-confirmed COVID-19 infection by a real-time PCR (RT-PCR) assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited for this study. Each hospital screened their lists of discharged patients at least 45 days after symptom onset. SARS-CoV-2-infected patients were divided into mild/moderate and severe disease groups according to the severity of their symptoms during hospitalisation. Patients’ epidemiological and medical histories, comorbidities, chronic treatments, and laboratory parameters were evaluated. Pulmonary function tests, the standardised 6-minute walk test (6 MWT) and chest computed tomography (CT) were also performed. The levels of proteases, their inhibitors, and shed receptors were measured in serum and induced sputum samples.

Results: A total of 100 patients with respiratory function tests were included in this study. The median number of days after the onset of symptoms was 104 (IQR 89.25, 126.75). COVID-19 was severe in 47% (47/100) of patients. CT was normal in 48% (48/100) of patients. Lung function was normal (FEV1 ≥80%, FVC ≥80%, FEV1/FVC ≥0.7, and diffusing capacity for carbon monoxide [DLCO] ≥80%) in 92% (92/100), 94% (94/100), 100% (100/100) and 48% (48/100) of patients, respectively. Multivariate analysis showed that a DLCO <80% (OR 5.92; 95%CI 2.28-15.37; p <0.0001) and a lower serum LDH level (OR 0.98; 95%CI 0.97-0.99) were associated with the severe disease group of SARS-CoV-2 during hospital stay.

Conclusions: A diffusion deficit (DLCO <80%) was still present after hospital discharge and was associated with the most severe SARS-CoV-2 cases.

Idioma: Inglés

DOI: 10.1016/j.cmi.2021.02.019

Año: 2021

Publicado en: Clinical Microbiology and Infection 27 (2021), 892 - 896
ISSN: 1198-743X

Factor impacto JCR: 13.31 (2021)

Categ. JCR: MICROBIOLOGY rank: 13 / 138 = 0.094 (2021) - Q1 - T1
Categ. JCR: INFECTIOUS DISEASES rank: 12 / 96 = 0.125 (2021) - Q1 - T1

Factor impacto CITESCORE: 16.5 - Medicine (Q1)

Factor impacto SCIMAGO: 3.111 - Medicine (miscellaneous) (Q1) - Infectious Diseases (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/COV20-00401

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Radiol. y Medicina Física (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)