Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Crichton, S. ; Belfrage, E. ; Collins, I.J. ; Doerholt, K. ; Judd, A. ; Le Coeur, S. ; Spoulou, V. ; Goodall, R. ; Scherpbier, H. ; Smit, C. ; Goetghebuer, T. ; Gibb, D.M. ; Noguera, A. ; Navarro, M.L. ; Ramos, J.T. ; Galli, L. ; Giaquinto, C. ; Thorne, C. ; Santa Ansone. ; Marczynska, M. ; Okhonskaia, L. ; de Tejada, BM. ; Jourdain, G. ; Decker, L. ; Ene, L. ; Hainaut, M. ; Van der Kelen, E. ; Delforge, M. ; de Martino, M. ; Tovo, PA. ; Patrizia, O. ; Larovere, D. ; Ruggeri, M. ; Faldella, G. ; Baldi, F. ; Badolato, R. ; Montagnani, C. ; Venturini, E. ; Lisi, C. ; Di Biagio, A. ; Taramasso, L. ; Giacomet, V. ; Erba, P. ; Esposito, S. ; Lipreri, R. ; Salvini, F. ; Tagliabue, C. ; Cellini, M. ; Bruzzese, E. ; Lo Vecchio, A. ; Rampon, O. ; Dona, D. ; Romano, A. ; Dodi, I. ; Maccabruni, A. ; Consolini, R. ; Bernardi, S. ; Kuekou, HT. ; Genovese, O. ; Olmeo, P. ; Cristiano, L. ; Mazza, A. ; Gabiano, C. ; Garazzino, S. ; Pellegatta, A. ; Pajkrt, D. ; Scherpbier, HJ. ; Weijsenfeld, AM. ; de Boer, CG. ; Jurriaans, S. ; Back, NKT. ; Zaaijer, HL. ; Berkhout, B. ; Cornelissen, MTE. ; Schinkel, CJ. ; Wolthers, KC. ; Fraaij, PLA. ; van Rossum, AMC. ; Vermont, CL. ; van der Knaap, LC. ; Visser, EG. ; Boucher, CAB. ; Koopmans, MPG. ; van Kampen, JJA. ; Pas, SD. ; Henriet, SSV. ; van de Flier, M. ; van Aerde, K. ; Strik-Albers, R. ; Rahamat-Langendoen, J. ; Stelma, FF. ; Scholvinck, EH. ; de Groot-de Jonge, H. ; Niesters, HGM. ; van Leer-Buter, CC. ; Knoester, M. ; Bont, LJ. ; Geelen, SPM. ; Wolfs, TFW. ; Nauta, N. ; Schuurman, R. ; Verduyn-Lunel, F. ; Wensing, AMJ. ; Reiss, P. ; Zaheri, S. ; Bezemer, DO. ; van Sighem, AI. ; Smit, C. ; Wit, FWMN. ; Hillebregt, M. ; de Jong, A. ; Woudstra, T. ; Bergsma, D. ; Grivell, S. ; Meijering, R. ; Raethke, M. ; Rutkens, T. ; de Groot, L. ; van den Akker, M. ; Bakker, Y. ; Bezemer, M. ; El Berkaoui, A. ; Geerlinks, J. ; Koops, J. ; Kruijne, E. ; Lodewijk, C. ; Lucas, E. ; van der Meer, R. ; Munjishvili, L. ; Paling, E. ; Peeck, B. ; Ree, C. ; Regtop, R. ; Ruijs, Y. ; van de Sande, L. ; Schoorl, M. ; Schnorr, P. ; Tuijn, E. ; Veenenberg, L. ; van der Vliet, S. ; Wisse, A. ; Witte, EC. ; Tuk, B. ; Popielska, J. ; Pokorska-Spiewak, M. ; Oldakowska, A. ; Zawadka, K. ; Coupland, U. ; Doroba, M. ; Voronin, E. ; Miloenko, M. ; Labutina, S. ; Soler-Palacin, P. ; Frick, MA. ; Perez-Hoyos, S. ; Mur, A. ; Lopez, N. ; Mendez, M. ; Mayol, L. ; Vallmanya, T. ; Calavia, O. ; Garcia, L. ; Coll, M. ; Pineda, V. ; Rius, N. ; Rovira, N. ; Duenas, J. ; Gamell, A. ; Fortuny, C. ; Noguera-Julian, A. ; Mellado, MJ. ; Escosa, L. ; Hortelano, MG. ; Sainz, T. ; Gonzalez-Tome, MI. ; Rojo, P. ; Blazquez, D. ; Prieto, L. ; Guillen, S. ; Saavedra, J. ; Santos, M. ; Munoz, MA. ; Ruiz, B. ; Mc Phee, CF. ; de Ory, SJ. ; Alvarez, S. ; Roa, MA. ; Beceiro, J. ; Martinez, J. ; Badillo, K. ; Apilanez, M. ; Pocheville, I. ; Garrote, E. ; Colino, E. ; Sirvent, JG. ; Garzon, M. ; Roman, V. ; Montesdeoca, A. ; Mateo, M. ; Munoz, MJ. ; Angulo, R. ; Neth, O. ; Falcon, L. ; Terol, P. ; Santos, JL. ; Moreno, D. ; Lendinez, F. ; Grande, A. ; Romero, FJ. ; Perez, C. ; Lillo, M. ; Losada, B. ; Herranz, M. ; Bustillo, M. ; Guerrero, C. ; Collado, P. (Universidad de Zaragoza) ; Couceiro, JA. ; Perez, A.

Resumen: Objective: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV.
Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand.
Methods: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters.
Results: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean.
Conclusion: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age.

Idioma: Inglés

DOI: 10.1097/QAD.0000000000002294

Año: 2019

Publicado en: AIDS (London, England) 33, 12 (2019), 1897-1910
ISSN: 0269-9370

Factor impacto JCR: 4.511 (2019)

Categ. JCR: INFECTIOUS DISEASES rank: 19 / 93 = 0.204 (2019) - Q1 - T1
Categ. JCR: VIROLOGY rank: 7 / 37 = 0.189 (2019) - Q1 - T1
Categ. JCR: IMMUNOLOGY rank: 49 / 158 = 0.31 (2019) - Q2 - T1

Factor impacto SCIMAGO: 2.447 - Immunology (Q1) - Infectious Diseases (Q1) - Immunology and Allergy (Q1)

Financiación: info:eu-repo/grantAgreement/ES/FECYT/FIPSE-240800-09
Financiación: info:eu-repo/grantAgreement/ES/FECYT/FIPSE-3608229-09
Financiación: info:eu-repo/grantAgreement/ES/FECYT/FIPSE-361910-10
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER-CoRISpe-RED RIS/RD06-0006-0021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER-CoRISpe-RED RIS/RD06-0006-0035
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI15-00694
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD12-0017-0035
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD12-0017-0037

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Pediatría (Dpto. Pediatría Radiol.Med.Fís)