Melatonin to rescue the aged heart: antiarrhythmic and antioxidant benefits

Segovia-Roldan, M. ; Diez, E.R. ; Pueyo, E. (Universidad de Zaragoza)

Resumen: Aging comes with gradual loss of functions that increase the vulnerability to disease, senescence, and death. The mechanisms underlying these processes are linked to a prolonged imbalance between damage and repair. Damaging mechanisms include oxidative stress, mitochondrial dysfunction, chronodisruption, inflammation, and telomere attrition, as well as genetic and epigenetic alterations. Several endogenous tissue repairing mechanisms also decrease. These alterations associated with aging affect the entire organism. The most devastating manifestations involve the cardiovascular system and may lead to lethal cardiac arrhythmias. Together with structural remodeling, electrophysiological and intercellular communication alterations during aging predispose to arrhythmic events. Despite the knowledge on repairing mechanisms in the cardiovascular system, effective antiaging strategies able to reduce the risk of arrhythmias are still missing. Melatonin is a promising therapeutic candidate due to its pleiotropic actions. This indoleamine regulates chronobiology and endocrine physiology. Of relevance, melatonin is an antiaging, antioxidant, antiapoptotic, antiarrhythmic, immunomodulatory, and antiproliferative molecule. This review focuses on the protective effects of melatonin on age-induced cardiac functional and structural alterations, potentially becoming a new fountain of youth for the heart.

Idioma: Inglés

DOI: 10.1155/2021/8876792

Año: 2021

Publicado en: Oxidative Medicine and Cellular Longevity 2021, 8876792 (2021), [18 pp.]
ISSN: 1942-0900

Factor impacto JCR: 7.31 (2021)

Categ. JCR: CELL BIOLOGY rank: 55 / 195 = 0.282 (2021) - Q2 - T1

Factor impacto CITESCORE: 9.3 - Medicine (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 1.233 - Biochemistry (Q1) - Medicine (miscellaneous) (Q1) - Cell Biology (Q1)

Tipo y forma: Revisión (Versión definitiva)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)