Bottom Effect in Atomic Force Microscopy Nanomechanics

Chiodini, Stefano (Universidad de Zaragoza) ; Ruiz-Rincón, Silvia ; Garcia, P.D. ; Martin, Santiago (Universidad de Zaragoza) ; Kettelhoit, K. ; Armenia, I. ; Werz, D.B. ; Cea, Pilar (Universidad de Zaragoza)

Resumen: In this work, the influence of the rigid substrate on the determination of the sample Young''s modulus, the so-called bottom-effect artifact, is demonstrated by an atomic force microscopy force-spectroscopy experiment. The nanomechanical properties of a one-component supported lipid membrane (SLM) exhibiting areas of two different thicknesses are studied: While a standard contact mechanics model (Sneddon) provides two different elastic moduli for these two morphologies, it is shown that Garcia''s bottom-effect artifact correction yields a unique value, as expected for an intrinsic material property. Remarkably, it is demonstrated that the ratio between the contact radius (and not only the indentation) and the sample thickness is the key parameter addressing the relevance of the bottom-effect artifact. The experimental results are validated by finite element method simulations providing a solid support to Garcia''s theory. The amphiphilic nature of the investigated material is representative of several kinds of lipids, suggesting that the results have far reaching implications for determining the correct Young''s modulus of SLMs. The generality of Garcia''s bottom-effect artifact correction allows its application to every kind of supported soft film.

Idioma: Inglés

DOI: 10.1002/smll.202000269

Año: 2020

Publicado en: Small 16, 35 (2020), 2000269 [8 pp]
ISSN: 1613-6810

Factor impacto JCR: 13.281 (2020)

Categ. JCR: CHEMISTRY, PHYSICAL rank: 14 / 162 = 0.086 (2020) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 25 / 333 = 0.075 (2020) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 13 / 106 = 0.123 (2020) - Q1 - T1
Categ. JCR: PHYSICS, CONDENSED MATTER rank: 7 / 69 = 0.101 (2020) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 18 / 178 = 0.101 (2020) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 11 / 160 = 0.069 (2020) - Q1 - T1

Factor impacto SCIMAGO: 3.785 - Biomaterials (Q1) - Biotechnology (Q1) - Chemistry (miscellaneous) (Q1) - Nanoscience and Nanotechnology (Q1) - Materials Science (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1) - Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/E31-17R
Financiación: info:eu-repo/grantAgreement/EUR/ERA-NET-COFUND/MagicCellGene Project 2016
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PCIN-2017-127

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Física (Dpto. Química Física)