Social defeat stress: mechanisms underlying the increase in rewarding effects of drugs of abuse

Montagud-Romero, Sandra ; Blanco-Gandía, María Carmen ; Reguilón, Marina D. ; Ferrer-Pérez, Carmen ; Ballestín, Raul ; Miñarro, José ; Rodríguez-Arias, Marta

Resumen: Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces longlasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short-and longterm consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.

Idioma: Inglés

DOI: 10.1111/ejn.14127

Año: 2018

Publicado en: EUROPEAN JOURNAL OF NEUROSCIENCE 48, 9 (2018), 2948-2970
ISSN: 0953-816X

Factor impacto JCR: 2.784 (2018)

Categ. JCR: NEUROSCIENCES rank: 142 / 266 = 0.534 (2018) - Q3 - T2

Factor impacto SCIMAGO: 1.501 - Neuroscience (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0005
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R

Tipo y forma: Artículo (PostPrint)