Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei

Rodríguez Arias, Marta ; Montagud Romero, Sandra ; Guardia Carrión, Ana María ; Ferrer Pérez, Carmen ; Perez Villalba, Ana ; Marco, Eva ; Lopez Gallardo, Meritxell ; Viveros, Maria Paz ; Miñarro, José

Resumen: The experience of social stress during adolescence is associated with higher vulnerability to drug use. Increases in the acquisition of cocaine self-administration, in the escalation of cocaine-seeking behavior, and in the conditioned rewarding effects of cocaine have been observed in rodents exposed to repeated social defeat (RSD). In addition, prolonged or severe stress induces a proinflammatory state with microglial activation and increased cytokine production. The aim of the present work was to describe the long-term effects induced by RSD during adolescence on the neuroinflammatory response and synaptic structure by evaluating different glial and neuronal markers. In addition to an increase in the conditioned rewarding effects of cocaine, our results showed that RSD in adolescence produced inflammatory reactivity in microglia that is prolonged into adulthood, affecting astrocytes and neurons of two reward-processing areas of the brain (the prelimbic cortex, and the nucleus accumbens core). Considered as a whole these results suggest that social stress experience modulates vulnerability to suffer a loss of glia-supporting functions and neuronal functional synaptic density due to drug consumption in later life.

Idioma: Inglés

DOI: 10.1371/journal.pone.0206421

Año: 2018

Publicado en: PLoS ONE 13, 10 (2018), 1-19
ISSN: 1932-6203

Factor impacto JCR: 2.776 (2018)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 23 / 69 = 0.333 (2018) - Q2 - T2

Factor impacto SCIMAGO: 1.1 - Agricultural and Biological Sciences (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0021
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R

Tipo y forma: Artículo (Versión definitiva)