Engineered nanostructured photocatalysts for cancer therapy

Bonet-Aleta, Javier (Universidad de Zaragoza) ; Garcia-Peiro, Jose I. (Universidad de Zaragoza) ; Hueso, Jose L. (Universidad de Zaragoza)

Resumen: The present review aims at highlighting recent advances in the development of photocatalysts devoted to cancer therapy applications. We pay especial attention to the engineering aspects of different nanomaterials including inorganic semiconductors, organic-based nanostructures, noble metal-based systems or synergistic hybrid heterostructures. Furthermore, we also explore and correlate structural and optical properties with their photocatalytic capability to successfully performing in cancer-related therapies. We have made an especial emphasis to introduce current alternatives to organic photosensitizers (PSs) in photodynamic therapy (PDT), where the effective generation of reactive oxidative species (ROS) is pivotal to boost the efficacy of the treatment. We also overview current efforts in other photocatalytic strategies to tackle cancer based on photothermal treatment, starvation therapy, oxidative stress unbalance via glutathione (GSH) depletion, biorthogonal catalysis or local relief of hypoxic conditions in tumor microenvironments (TME).

Idioma: Inglés

DOI: 10.3390/catal12020167

Año: 2022

Publicado en: Catalysts 12, 2 (2022), 167 [28 pp.]
ISSN: 2073-4344

Factor impacto JCR: 3.9 (2022)

Categ. JCR: CHEMISTRY, PHYSICAL rank: 71 / 161 = 0.441 (2022) - Q2 - T2

Factor impacto CITESCORE: 6.3 - Environmental Science (Q1) - Chemistry (Q2) - Chemical Engineering (Q2)

Factor impacto SCIMAGO: 0.69 - Physical and Theoretical Chemistry (Q2) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/MCIU/FPU18/04618

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)