Synthesis and antiproliferative study of phosphorescent multimetallic Re(I)/Au(I) complexes containing fused imidazo[4, 5-f]-1, 10-phenanthroline core

Luengo, Andres ; Marzo, Isabel (Universidad de Zaragoza) ; Fernandez-Moreira, Vanesa (Universidad de Zaragoza) ; Gimeno, M. Concepcion

Resumen: Five heterobimetallic Re-I/Au-I and a tri-metallic Re-I/Au-I/Re-I species following the formulas fac-ReCl (CO)(3)(NNCAuR)](0/+) and (fac-ReCl (CO)(3)(NNC)])(2)Au](+), where R is an iodide (1), phenylacetylene (2), dodecanethiol (3), 2, 3, 4, 6-tetra-O-acetyl-1-thio-beta-D-glucopyranose (4) and JohnPhos (5) and NNC is the fused imidazo4, 5-f]-1, 10-phenanthroline heterotopic ligand, were synthesised and fully characterised by a variety of spectroscopic and analytical techniques. The resultant complexes are luminescent in the orange region, revealing classical metal-to-ligand charge transfer ((MLCT)-M-3) ((Re (d pi) -> (NNC)(pi*)) emission in aerated DMSO solution. The red shifted emission observed on going from 3 to 4 suggests that the electronic properties of the gold ancillary ligand are implicated in the emissive properties. Antiproliferative activity in tumour cell lines, lung (A549) and cervix (HeLa) cells revealed that only complex 4 containing a 2, 3, 4, 6-tetra-O-acetyl-1-thio-beta-D-glucopyranose as gold ancillary ligand possesses certain cytotoxicity in both cell lines.

Idioma: Inglés

DOI: 10.1002/aoc.6661

Año: 2022

Publicado en: APPLIED ORGANOMETALLIC CHEMISTRY e6661 (2022), [11 pp]
ISSN: 0268-2605

Factor impacto JCR: 3.9 (2022)

Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 8 / 42 = 0.19 (2022) - Q1 - T1
Categ. JCR: CHEMISTRY, APPLIED rank: 22 / 72 = 0.306 (2022) - Q2 - T1

Factor impacto CITESCORE: 7.3 - Chemistry (Q1)

Factor impacto SCIMAGO: 0.518 - Inorganic Chemistry (Q2) - Chemistry (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/PID2019-104379RB-C21
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097836-J-I00
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RYC2018-025872

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)