Selective IgA deficiency and presumptive polyclonal spike in the beta fraction in a dog with leishmaniosis

Villanueva Saz, S. (Universidad de Zaragoza) ; Martinez Lostao, L. (Universidad de Zaragoza) ; Yzuel, A. ; Fernández, A. (Universidad de Zaragoza) ; Verde, M. (Universidad de Zaragoza)

Resumen: A 1-year-old, entire, crossbred, female dog examined for apathy, lethargy, unilateral nosebleed of 2-month duration and the presence of symmetrical ulcerative dermatitis (small ulcers covered by a haemorrhagic crust and surrounded by alopecia on the tip of the ear pinna). Laboratory alterations included anaemia and hyperglobulinemia with a presumptive polyclonal spike in the beta fraction. High antibody levels to Leishmania infantum were detected by enzyme-linked immunosorbent assay. An anti-Leishmania therapeutic protocol was established and a reduction of the anti-Leishmania antibodies was detected by an end point sera dilution enzyme-linked immunosorbent assay during the first weeks of therapeutic protocol, while C-reactive protein concentration was reduced during the period of time when meglumine antimoniate was administered. A good clinical response to the treatment was detected after initiating the anti-Leishmania treatment. Quantitative serology is useful in the short-term, because using a two-fold serial dilution technique correlates with the clinical response. © 2022 British Veterinary Association.

Idioma: Inglés

DOI: 10.1002/vrc2.412

Año: 2022

Publicado en: Veterinary Record Case Reports 10, 3 (2022), e412 [6 pp]
ISSN: 2052-6121

Factor impacto CITESCORE: 0.4 - Veterinary (Q4)

Factor impacto SCIMAGO: 0.176 - Veterinary (miscellaneous) (Q3)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)