Epigenetic clocks in relapse after a first episode of schizophrenia

Segura, Àlex-González ; Prohens, Llucia ; Mezquida, Gisela ; Amoretti, Silvia ; Bioque, Miquel ; Ribeiro, María ; Gurriarán-Bas, Xaquin ; Rementería, Lide ; Berge, Daniel ; Rodriguez-Jimenez, Roberto ; Roldán, Alexandra ; Pomarol-Clotet, Edith ; Ibáñez, Angela ; Usall, Judith ; García-Portilla, Maria Paz ; Cuesta, Manuel J. ; Parellada, Mara ; González-Pinto, Ana ; Berrocoso, Esther ; Bernardo, Miquel ; Mas, Sergi ; González-Díaz, Jairo M. ; Arbelo, Néstor ; González-Peñas, Javier ; Pina-Camacho, Laura ; Diestre, Alba ; Selma, Judit ; Zorrilla, Iñaki ; López, Purificación ; Trabsa, Amira ; Monserrat, Clara ; Sanchez-Pastor, Luis ; Nuñez-Doyle, Aggie ; Fatjó-Vilas, Mar ; Sarró, Salvador ; Butjosa, Anna ; Pardo, Marta ; López-Ilundain, Jose M. ; Sánchez Torres, Ana M. ; Saiz-Ruiz, Jerónimo ; Ochoa-Mangado, Enriqueta ; RIevero, Olga ; De la Cámara, Concepción (Universidad de Zaragoza) ; Segarra Echevarría, Rafael ; González-Blanco, Leticia

Resumen: The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.

Idioma: Inglés

DOI: 10.1038/s41537-022-00268-2

Año: 2022

Publicado en: Schizophrenia 8 (2022), 61 [8 pp.]
ISSN: 2754-6993

Factor impacto JCR: 0.0 (2022)

Categ. JCR: PSYCHIATRY

Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERSAM
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI08-0208
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)