Handgrip strength and respiratory disease mortality: Longitudinal analyses from SHARE

Mey, R. ; Calatayud, J. ; Casaña, J. ; Torres-Castro, R. ; Cuenca-Martínez, F. ; Suso-Martí, L. ; Andersen, L.L. ; López-Bueno, R.

Resumen: Background: While the association between handgrip strength and all-cause mortality is more deeply explored, no previous studies have been specifically focused on handgrip strength and respiratory disease mortality. The purpose of the study was to investigate the association between handgrip strength and respiratory disease mortality in a large representative sample. Methods: Individuals aged 50 or over from 27 European countries and Israel participated in this longitudinal study. Data on handgrip strength and all-cause and respiratory disease mortality were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7. We estimated the sub hazard ratios (SHRs) for respiratory disease mortality using a Fine-Gray sub-distribution method with both time-varying exposure and covariates and mortality due to other causes as competing risk. Furthermore, we assessed dose‐response associations of handgrip strength (modelled as a continuous exposure) with respiratory disease mortality using restricted cubic splines and estimated hazard ratios (HRs). Results: We included 60,883 men and 74,904 women with a mean age of 63.6 (SD 9.7) years at study entry. During a median (interquartile range) of 7.4 years of follow-up 565 (0.4%) participants died due to respiratory diseases. The increase of 1 single kg of handgrip strength showed a 6% incidence reduction on respiratory disease mortality (SHR, 0.94; 95%CI, 0.92-0.96) after adjusting for potential confounders. Furthermore, each kg increase of handgrip strength reduced respiratory disease mortality risk in a dose-response fashion and a significant threshold for values of 41 kg (HR, 0.49; 95%CI, 0.26-0.92) and higher was identified. Conclusions: Higher handgrip strength is associated with lower mortality due to respiratory disease. Intervention studies are needed to determine whether strength training in respiratory disease patients can prevent premature mortality.

Idioma: Inglés

DOI: 10.1016/j.pulmoe.2022.09.007

Año: 2022

Publicado en: Pulmonolgy
ISSN: 2531-0429

Factor impacto JCR: 11.7 (2022)

Categ. JCR: RESPIRATORY SYSTEM rank: 5 / 66 = 0.076 (2022) - Q1 - T1

Factor impacto CITESCORE: 13.0 - Medicine (Q1)

Factor impacto SCIMAGO: 1.641 - Pulmonary and Respiratory Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/211909/EU/Upgrading the Survey of Health, Ageing and Retirement in Europe – preparatory phase/SHARE-PREP
Financiación: info:eu-repo/grantAgreement/EC/FP7/227822/EU/Longitudinal Enhancement and Access imProvement of the SHARE infrastructure/SHARE_LEAP
Financiación: info:eu-repo/grantAgreement/EC/FP7/261982/EU/Multinational Advancement of Research Infrastructures on Ageing/SHARE_M4
Financiación: info:eu-repo/grantAgreement/EC/FP7/283646/EU/Data Service Infrastructure for the Social Sciences and Humanities/DASISH
Financiación: info:eu-repo/grantAgreement/EC/HS/QLK6-CT-2001-00360/EU/Survey on health, ageing and retirement in europe (SHARE)/SHARE
Financiación: info:eu-repo/grantAgreement/EC/H2020/654221/EU/Synergies for Europe's Research Infrastructures in the Social Sciences/SERISS
Financiación: info:eu-repo/grantAgreement/EC/H2020/676536/EU/Achieving world-class standards in all SHARE countries/SHARE-DEV3
Financiación: info:eu-repo/grantAgreement/EC/H2020/823782/EU/Social Sciences & Humanities Open Cloud/SSHOC
Financiación: info:eu-repo/grantAgreement/EC/H2020/870628/EU/Cohesion in further developing and innovating SHARE across all 28 member countries/SHARE-COHESION

Tipo y forma: Artículo (Versión definitiva)