Photonic and magnetic materials for on-demand local drug delivery

Armenia, Ilaria ; Cuestas Ayllón, Carlos ; Torres Herrero, Beatriz ; Bussolari, Francesca ; Alfranca, Gabriel ; Grazú, Valeria ; Martínez de la Fuente, Jesús

Resumen: Nanomedicine has been considered a promising tool for biomedical research and clinical practice in the 21st century because of the great impact nanomaterials could have on human health. The generation of new smart nanomaterials, which enable time- and space-controlled drug delivery, improve the limitations of conventional treatments, such as non-specific targeting, poor biodistribution and permeability. These smart nanomaterials can respond to internal biological stimuli (pH, enzyme expression and redox potential) and/or external stimuli (such as temperature, ultrasound, magnetic field and light) to further the precision of therapies. To this end, photonic and magnetic nanoparticles, such as gold, silver and iron oxide, have been used to increase sensitivity and responsiveness to external stimuli. In this review, we aim to report the main and most recent systems that involve photonic or magnetic nanomaterials for external stimulus-responsive drug release. The uniqueness of this review lies in highlighting the versatility of integrating these materials within different carriers. This leads to enhanced performance in terms of in vitro and in vivo efficacy, stability and toxicity. We also point out the current regulatory challenges for the translation of these systems from the bench to the bedside, as well as the yet unresolved matter regarding the standardization of these materials.

Idioma: Inglés

DOI: 10.1016/j.addr.2022.114584

Año: 2022

Publicado en: ADVANCED DRUG DELIVERY REVIEWS 191 (2022), 114584 [38 pp.]
ISSN: 0169-409X

Factor impacto JCR: 16.1 (2022)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 4 / 278 = 0.014 (2022) - Q1 - T1

Factor impacto CITESCORE: 23.3 - Pharmacology, Toxicology and Pharmaceutics (Q1)

Factor impacto SCIMAGO: 2.982 - Pharmaceutical Science (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/E15-17R
Financiación: info:eu-repo/grantAgreement/EC/H2020/829010/EU/Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices/PRIME
Financiación: info:eu-repo/grantAgreement/EC/H2020/829162/EU/Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation/HOTZYMES
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CB06-01/00263
Financiación: info:eu-repo/grantAgreement/ES/MICINN/BIO2017-84246-C2-1-R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-118485RB-I00

Tipo y forma: Artículo (Versión definitiva)