Europium doped-double sodium bismuth molybdate nanoparticles as contrast agents for luminescence bioimaging and X-ray computed tomography

Calderón-Olvera, Roxana M. ; Núñez, Nuria O. ; González-Mancebo, Daniel ; Monje-Moreno, Jose M. ; Muñoz-Rui, Manuel J. ; Gómez-González, Elisabet ; Arroyo, Encarnación ; Torres-Herrero, Beatriz ; Martínez de la Fuente, Jesús ; Ocaña, Manuel

Resumen: A one-pot method for the synthesis of uniform Eu3+-doped NaBi(MoO4)2 nanoparticles with an ellipsoidal shape and tetragonal crystal structure functionalized with polyacrylic acid is reported for the first time in the literature. The method is based on a homogeneous precipitation reaction from solutions in an ethylene glycol/water medium containing appropriate bismuth, sodium, and molybdate precursors and polyacrylic acid. The luminescence properties (excitation and emission spectra and luminescence lifetime) of such nanoparticles are evaluated for different Eu3+ doping levels, finding an intense red emission for all synthesized samples. The X-ray attenuation properties of the nanoparticles have been also analyzed, which were found to be better than those of a commercially computed tomography contrast agent (iohexol). The dispersibility of the nanoparticles in a physiological medium was also analyzed, finding that they could be well dispersed in a 2-N-morpholinoethanesulfonic acid monohydrate medium (pH = 6.5). Finally, the cell viability of such a phosphor has been analyzed using MIA-PaCa-2 cells and its in vivo toxicity has been evaluated using the nematode Caenorhabditis elegans model finding no significant toxicity in both cases up to a nanoparticle concentration of 100 μg mL−1, which is within the range required for most in vivo applications. The developed Eu3+-doped NaBi(MoO4)2 nanoparticles are, therefore, excellent candidates for their use as bimodal probes for luminescence imaging and X-ray computed tomography.

Idioma: Inglés

DOI: 10.1039/d2qi02664c

Año: 2023

Publicado en: Inorganic Chemistry Frontiers (2023), [11 pp.]
ISSN: 2052-1545

Factor impacto JCR: 6.1 (2023)

Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 3 / 44 = 0.068 (2023) - Q1 - T1

Factor impacto CITESCORE: 10.4 - Inorganic Chemistry (Q1)

Factor impacto SCIMAGO: 1.255 - Inorganic Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/E15-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CB06-01/00263
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094426-B-I00

Tipo y forma: Artículo (Versión definitiva)