Maternal and cord blood betatrophin (angiopoietin-like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta-analysis, and meta-regression
Pérez-López, Faustino R. ; Yuan, Junhua ; Sánchez-Prieto, Manuel ; López-Baena, María T. ; Pérez-Roncero, Gonzalo R. ; Varikasuvu, Seshadri Reddy
Resumen: Aims: This systematic review and meta-analysis examined maternal and cord blood betatrophin levels in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls.
Material and Methods: PubMed, Cochrane Library, Embase, LILACS, WangFang, and China National Knowledge Infrastructure were searched for literature from inception until May 2022. The primary outcomes were maternal and cord blood betatrophin levels. A random-effect meta-analysis was used to estimate the pooled results. The mean differences (MDs) or standardised MDs (SMD) and their 95% confidence intervals (CIs) were calculated. I2 tests were used to evaluate the heterogeneity. The quality of studies was evaluated using the Newcastle–Ottawa Scale.
Results: Betatrophin levels were reported in 22 studies with a total of 3034 pregnant women, and in seven studies including cord blood from 456 infants. Women with GDM display higher betatrophin levels than the normoglycemic controls (SMD = 0.85, 95% CI: 0.38–1.31) during the second half of the pregnancy. The sensitivity analysis indicated that no single study had significantly influenced the betatrophin overall outcomes. There was heterogeneity between the studies as evidenced by high I2 values. Meta-regression analysis indicated a significant regression coefficient for maternal betatrophin and glycosilated haemoglobin. There was no significant difference in cord blood betatrophin in infants from women with and without GDM (SMD = 0.34, 95% CI: −0.15–0.83). Women with GDM also had significantly higher insulin, glucose, glycosylated haemoglobin, HOMA-IR, LDL-cholesterol, HDL-cholesterol, triglycerides, and body mass index compared with the normoglycemic controls.
Conclusions: Maternal betatrophin levels were higher in women with GDM than in the normoglycemic controls. There was no difference in cord blood betatrophin.
Idioma: Inglés
DOI: 10.1002/dmrr.3612
Año: 2023
Publicado en: Diabetes/metabolism research and reviews 39, 4 (2023), e3612 [20 pp.]
ISSN: 1520-7552
Factor impacto JCR: 4.6 (2023)
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 36 / 186 = 0.194 (2023) - Q1 - T1
Factor impacto CITESCORE: 17.2 - Internal Medicine (Q1) - Endocrinology (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Factor impacto SCIMAGO: 1.991 - Endocrinology (Q1) - Internal Medicine (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.
Exportado de SIDERAL (2024-11-22-11:58:19)
Visitas y descargas
Material and Methods: PubMed, Cochrane Library, Embase, LILACS, WangFang, and China National Knowledge Infrastructure were searched for literature from inception until May 2022. The primary outcomes were maternal and cord blood betatrophin levels. A random-effect meta-analysis was used to estimate the pooled results. The mean differences (MDs) or standardised MDs (SMD) and their 95% confidence intervals (CIs) were calculated. I2 tests were used to evaluate the heterogeneity. The quality of studies was evaluated using the Newcastle–Ottawa Scale.
Results: Betatrophin levels were reported in 22 studies with a total of 3034 pregnant women, and in seven studies including cord blood from 456 infants. Women with GDM display higher betatrophin levels than the normoglycemic controls (SMD = 0.85, 95% CI: 0.38–1.31) during the second half of the pregnancy. The sensitivity analysis indicated that no single study had significantly influenced the betatrophin overall outcomes. There was heterogeneity between the studies as evidenced by high I2 values. Meta-regression analysis indicated a significant regression coefficient for maternal betatrophin and glycosilated haemoglobin. There was no significant difference in cord blood betatrophin in infants from women with and without GDM (SMD = 0.34, 95% CI: −0.15–0.83). Women with GDM also had significantly higher insulin, glucose, glycosylated haemoglobin, HOMA-IR, LDL-cholesterol, HDL-cholesterol, triglycerides, and body mass index compared with the normoglycemic controls.
Conclusions: Maternal betatrophin levels were higher in women with GDM than in the normoglycemic controls. There was no difference in cord blood betatrophin.
Idioma: Inglés
DOI: 10.1002/dmrr.3612
Año: 2023
Publicado en: Diabetes/metabolism research and reviews 39, 4 (2023), e3612 [20 pp.]
ISSN: 1520-7552
Factor impacto JCR: 4.6 (2023)
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 36 / 186 = 0.194 (2023) - Q1 - T1
Factor impacto CITESCORE: 17.2 - Internal Medicine (Q1) - Endocrinology (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Factor impacto SCIMAGO: 1.991 - Endocrinology (Q1) - Internal Medicine (Q1) - Endocrinology, Diabetes and Metabolism (Q1)
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.Exportado de SIDERAL (2024-11-22-11:58:19)
Enlace permanente:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Artículos
Registro creado el 2023-06-21, última modificación el 2024-11-25