000128221 001__ 128221
000128221 005__ 20231129155502.0
000128221 0247_ $$2doi$$a10.1186/s13567-023-01208-3
000128221 0248_ $$2sideral$$a135614
000128221 037__ $$aART-2023-135614
000128221 041__ $$aeng
000128221 100__ $$aSola, Diego$$uUniversidad de Zaragoza
000128221 245__ $$aHeterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease
000128221 260__ $$c2023
000128221 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128221 5203_ $$aPrion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrPC) into the pathological prion protein (PrPSc). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrPSc was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrPSc deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD.
000128221 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128221 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128221 700__ $$aTran, Linh
000128221 700__ $$aVåge, Jørn
000128221 700__ $$aMadslien, Knut
000128221 700__ $$aVuong, Tram T.
000128221 700__ $$aKorpenfelt, Sirkka Liisa
000128221 700__ $$aÅgren, Erik O.
000128221 700__ $$aAverhed, Gustav
000128221 700__ $$aNöremark, Maria
000128221 700__ $$aSörén, Kaisa
000128221 700__ $$aIsaksson, Mats
000128221 700__ $$0(orcid)0000-0001-5105-6133$$aAcín, Cristina$$uUniversidad de Zaragoza
000128221 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, Juan José$$uUniversidad de Zaragoza
000128221 700__ $$aGavier-Widén, Dolores
000128221 700__ $$aBenestad, Sylvie L.
000128221 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000128221 773__ $$g54 (2023), 74 [15 pp]$$pVet. res.$$tVeterinary Research$$x0928-4249
000128221 8564_ $$s2718093$$uhttps://zaguan.unizar.es/record/128221/files/texto_completo.pdf$$yVersión publicada
000128221 8564_ $$s2388317$$uhttps://zaguan.unizar.es/record/128221/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128221 909CO $$ooai:zaguan.unizar.es:128221$$particulos$$pdriver
000128221 951__ $$a2023-11-29-15:04:40
000128221 980__ $$aARTICLE