Evaluation of PEG-b-polycarbonates self-assemblies containing azobenzene or coumarin moieties as nanocarriers using paclitaxel as a model hydrophobic drug

Roche, Alejandro (Universidad de Zaragoza) ; Morcuende-Ventura, Violeta ; Tejedor, Rosa M. (Universidad de Zaragoza) ; Oriol, Luis (Universidad de Zaragoza) ; Abian, Olga (Universidad de Zaragoza) ; Piñol, Milagros (Universidad de Zaragoza)

Resumen: The work assesses the performance of nanocarriers from amphiphilic block copolymers with functional azobenzene or coumarin moieties for delivery of paclitaxel. Placlitaxel was encapsulated by the nanoprecipitation method. Characterisations were performed by DLS, TEM, Zeta potential and HPLC. Cell viability was investigated in HeLa and Huh-5-2-cell lines. Coumarin-containing polymeric micelles (Dh = 26 ± 2 nm, PDI = 0.28, ζ = ‒22.9 ± 3.6 mV) with 11.2 ± 0.5%w/w drug loading showed enhanced cytotoxicity in HeLa cells (IC50 < 0.02 nM) compared to free paclitaxel (IC50 = 0.17 ± 0.02 nM). Azobenzene-containing polymeric vesicles (Dh = 390 ± 20 nm, PDI = 0.24, ζ = ‒33.2 ± 5.0 mV) with a 6.8 ± 0.4%w/w drug loading showed increased cytotoxicity under 530 nm light (IC50 = 0.0114 ± 0.00033 nM) in HeLa cells due to a stimulated delivery of paclitaxel. Effectivity of these block copolymers as paclitaxel nanovectors and light stimulated release has been demonstrated.

Idioma: Inglés

DOI: 10.1080/02652048.2022.2061621

Año: 2022

Publicado en: Journal of microencapsulation 39, 3 (2022), 276-287
ISSN: 0265-2048

Factor impacto JCR: 3.9 (2022)

Categ. JCR: CHEMISTRY, APPLIED rank: 22 / 72 = 0.306 (2022) - Q2 - T1
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 102 / 278 = 0.367 (2022) - Q2 - T2
Categ. JCR: ENGINEERING, CHEMICAL rank: 53 / 141 = 0.376 (2022) - Q2 - T2

Factor impacto CITESCORE: 6.2 - Pharmacology, Toxicology and Pharmaceutics (Q2) - Chemistry (Q2) - Chemical Engineering (Q2)

Factor impacto SCIMAGO: 0.511 - Organic Chemistry (Q2) - Colloid and Surface Chemistry (Q2) - Physical and Theoretical Chemistry (Q2) - Pharmaceutical Science (Q2) - Bioengineering (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B25-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA/E47-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI15-00663-Investing in your future
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)