000132136 001__ 132136
000132136 005__ 20240301161206.0
000132136 0247_ $$2doi$$a10.1002/smll.202309283
000132136 0248_ $$2sideral$$a137297
000132136 037__ $$aART-2024-137297
000132136 041__ $$aeng
000132136 100__ $$aKirbas Cilingir, Emel
000132136 245__ $$aSmall Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment
000132136 260__ $$c2024
000132136 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132136 5203_ $$aThe appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in the literature, copper chlorophyllin‐based carbon dots (Chl‐D CDs) are successfully synthesized. Chl‐D CDs exhibit unique spectroscopic traits and are found to induce a Fenton‐like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic and apoptotic pathways. To bolster the therapeutic impact of Chl‐D CDs, a widely used cancer drug, temozolomide, is linked to their surface, yielding a synergistic effect with PDT and chemotherapy. Chl‐D CDs' biocompatibility in immune cells and in vivo models showed great clinical potential.Proteomic analysis was conducted to understand Chl‐D CDs' underlying cancer treatment mechanism. The study underscores the role of reactive oxygen species formation and pointed toward various oxidative stress modulators like aldolase A (ALDOA), aldolase C (ALDOC), aldehyde dehydrogenase 1B1 (ALDH1B1), transaldolase 1 (TALDO1), and transketolase (TKT), offering a deeper understanding of the Chl‐D CDs' anticancer activity. Notably, the Chl‐D CDs' capacity to trigger a Fenton‐like reaction leads to enhanced PDT efficiencies through ferroptotic and apoptotic pathways. Hence, it is firmly believed that the inherent attributes of Chl‐CDs can lead to a secure and efficient combined cancer therapy.
000132136 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135911
000132136 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000132136 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000132136 700__ $$aBesbinar, Omur
000132136 700__ $$aGiro, Linda
000132136 700__ $$aBartoli, Mattia
000132136 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza
000132136 700__ $$aMintz, Keenan J.
000132136 700__ $$aAydogan, Yagmur
000132136 700__ $$aGarber, Jordan M.
000132136 700__ $$aTurktas, Mine
000132136 700__ $$aEkim, Okan
000132136 700__ $$aCeylan, Ahmet
000132136 700__ $$aUnal, Mehmet Altay
000132136 700__ $$aEnsoy, Mine
000132136 700__ $$aAri, Fikret
000132136 700__ $$aOzgenç Çinar, Ozge
000132136 700__ $$aOzturk, Berfin Ilayda
000132136 700__ $$aGokce, Cemile
000132136 700__ $$aCansaran-Duman, Demet
000132136 700__ $$aBraun, Markus
000132136 700__ $$aWachtveitl, Josef
000132136 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, Jesus$$uUniversidad de Zaragoza
000132136 700__ $$aDelogu, Lucia Gemma
000132136 700__ $$aTagliaferro, Alberto
000132136 700__ $$aYilmazer, Açelya
000132136 700__ $$aLeblanc, Roger M.
000132136 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000132136 773__ $$g(2024), 2309283 [18 pp.]$$pSmall$$tSmall$$x1613-6810
000132136 8564_ $$s3120138$$uhttps://zaguan.unizar.es/record/132136/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-01-17
000132136 8564_ $$s1743818$$uhttps://zaguan.unizar.es/record/132136/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-01-17
000132136 909CO $$ooai:zaguan.unizar.es:132136$$particulos$$pdriver
000132136 951__ $$a2024-03-01-14:50:19
000132136 980__ $$aARTICLE