000134903 001__ 134903
000134903 005__ 20240503133220.0
000134903 0247_ $$2doi$$a10.3389/fvets.2024.1325072
000134903 0248_ $$2sideral$$a138382
000134903 037__ $$aART-2024-138382
000134903 041__ $$adeu
000134903 100__ $$aAbad-Fau, Ana$$uUniversidad de Zaragoza
000134903 245__ $$aMultidrug resistance in pathogenic Escherichia coli isolates from urinary tract infections in dogs, Spain
000134903 260__ $$c2024
000134903 5060_ $$aAccess copy available to the general public$$fUnrestricted
000134903 5203_ $$aEscherichia coli (E. coli) is a pathogen frequently isolated in cases of urinary tract infections (UTIs) in both humans and dogs and evidence exists that dogs are reservoirs for human infections. In addition, E. coli is associated to increasing antimicrobial resistance rates. This study focuses on the analysis of antimicrobial resistance and the presence of selected virulence genes in E. coli isolates from a Spanish dog population suffering from UTI. This collection of isolates showed an extremely high level of phenotypic resistance to 1st–3rd generation cephalosporins, followed by penicillins, fluoroquinolones and amphenicols. Apart from that, 13.46% of them were considered extended-spectrum beta-lactamase producers. An alarmingly high percentage (71.15%) of multidrug resistant isolates were also detected. There was a good correlation between the antimicrobial resistance genes found and the phenotypic resistance expressed. Most of the isolates were classified as extraintestinal pathogenic E. coli, and two others harbored virulence factors related to diarrheagenic pathotypes. A significant relationship between low antibiotic resistance and high virulence factor carriage was found, but the mechanisms behind it are still poorly understood. The detection of high antimicrobial resistance rates to first-choice treatments highlights the need of constant antimicrobial resistance surveillance, as well as continuous revision of therapeutic guidelines for canine UTI to adapt them to changes in antimicrobial resistance patterns.
000134903 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000134903 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000134903 700__ $$0(orcid)0000-0002-4213-2904$$aSevilla, Eloisa$$uUniversidad de Zaragoza
000134903 700__ $$aOro, Ainara
000134903 700__ $$0(orcid)0000-0001-6016-4726$$aMartín-Burriel, Inmaculada$$uUniversidad de Zaragoza
000134903 700__ $$0(orcid)0000-0001-6629-6842$$aMoreno, Bernardino$$uUniversidad de Zaragoza
000134903 700__ $$0(orcid)0000-0001-9778-6545$$aMorales, Mariano$$uUniversidad de Zaragoza
000134903 700__ $$0(orcid)0000-0002-2746-3932$$aBolea, Rosa$$uUniversidad de Zaragoza
000134903 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000134903 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000134903 773__ $$g11 (2024), 15 pp.$$pFront. vet. sci.$$tFrontiers in Veterinary Science$$x2297-1769
000134903 8564_ $$s1881705$$uhttps://zaguan.unizar.es/record/134903/files/texto_completo.pdf$$yVersión publicada
000134903 8564_ $$s2129521$$uhttps://zaguan.unizar.es/record/134903/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000134903 909CO $$ooai:zaguan.unizar.es:134903$$particulos$$pdriver
000134903 951__ $$a2024-05-03-11:07:18
000134903 980__ $$aARTICLE