Facilitated Central Pain Mechanisms Across the Menstrual Cycle in Dysmenorrhea and Enlarged Pain Distribution in Women With Longer Pain History

Fortún-Rabadán, Rocío ; Boudreau, Shellie A. ; Bellosta-López, Pablo ; Herrero, Pablo (Universidad de Zaragoza) ; Graven-Nielsen, Thomas ; Doménech-García, Víctor

Resumen: Dysmenorrhea (DYS), or recurrent menstrual pain, is a highly prevalent pain condition among otherwise healthy women. However, the progression of DYS over time and the influence of the menstrual cycle phases need to be better understood. While the location and distribution of pain have been used to assess pain mechanisms in other conditions, they are unexplored in DYS. Thirty otherwise healthy women with severe DYS and 30 healthy control women were recruited into 3 subgroups (n = 10) according to the length of their menstrual history (<5, 5–15, or>15 years since menarche). The intensity and distribution of menstrual pain were recorded. Pressure pain thresholds at abdominal, hip, and arm sites, pressure-induced pain distribution, temporal summation of pain, and pain intensity after pressure cessation over the gluteus medius were assessed at 3 menstrual cycle phases. Compared with the healthy control women, those with DYS showed lower pressure pain thresholds in every site and menstrual cycle phase (P < .05), enlarged pressure-induced pain areas during menstruations (P < .01), and increased temporal summation and pain intensity after pressure cessation in the overall menstrual cycle (P < .05). Additionally, these manifestations were enhanced during the menstrual and premenstrual phases compared to ovulation in women with DYS (P < .01). Women with long-term DYS demonstrated enlarged pressure-induced pain distribution, enlarged menstrual pain areas, and more days with severe menstrual pain compared to the short-term DYS subgroup (P < .01). Pressure-induced and menstrual pain distributions were strongly correlated (P < .001). These findings suggest that severe DYS is a progressive condition underscored by facilitated central pain mechanisms associated with pain recurrence and exacerbation.

Idioma: Inglés

DOI: 10.1016/j.jpain.2023.04.005

Año: 2023

Publicado en: JOURNAL OF PAIN 24, 9 (2023), 1541-1554
ISSN: 1526-5900

Factor impacto JCR: 4.0 (2023)

Categ. JCR: CLINICAL NEUROLOGY rank: 51 / 280 = 0.182 (2023) - Q1 - T1
Categ. JCR: NEUROSCIENCES rank: 86 / 310 = 0.277 (2023) - Q2 - T1

Factor impacto CITESCORE: 6.3 - Neurology (clinical) (Q1) - Anesthesiology and Pain Medicine (Q1) - Neurology (Q2)

Factor impacto SCIMAGO: 1.339 - Anesthesiology and Pain Medicine (Q1) - Neurology (clinical) (Q1) - Neurology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MCIU/FPU19-05237

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Fisioterapia (Dpto. Fisiatría y Enfermería)