Reshaping treatment paradigm in actinic keratosis by using a modified Delphi questionnaire
Dirschka, Thomas ; Ardigò, Marco ; Fargnoli, Maria Concetta ; Ferrándiz-Pulido, Carla ; Gilaberte, Yolanda (Universidad de Zaragoza) ; Hadshiew, Ina ; Peris, Ketty ; Szeimies, Rolf-Markus
Resumen: Purpose
Actinic keratosis (AK) is the main precursor of invasive cutaneous squamous cell carcinoma (cSCC). Since it is impossible to predict which lesions will progress to cSCC, early treatment of AK is crucial. Although AK treatments are effective, some are associated with local skin reactions that may impact treatment compliance and effectiveness. The aim of this modified Delphi study was to review the efficacy and safety of the different AK treatments, gain an understanding of the dermatologists’ perspectives on their use, and provide guidelines for clinical practice.
Materials and methods
This document corresponds to a modified Delphi consensus survey, based on a literature review and a single round of questionnaire.
Results
The Delphi questionnaire was completed by 73 dermatologists from Germany, Italy, and Spain. Agreement was achieved for 78% of statements, while 11% showed discrepancies or were rejected.
Conclusions
Key findings emphasize the importance of patient-centered approaches and treatment attributes beyond efficacy (e.g. tolerability or adherence). Understanding the mechanisms of action of treatments is vital for managing patients’ and clinicians’ expectations and optimizing outcomes. Alternative strategies for evaluating efficacy, including the Actinic Keratosis Area and Severity Index (AKASI) score and lesion reduction from baseline, were also highlighted.
Idioma: Inglés
DOI: 10.1080/09546634.2025.2487657
Año: 2025
Publicado en: JOURNAL OF DERMATOLOGICAL TREATMENT 36, 1 (2025), 2487657 [7 pp.]
ISSN: 0954-6634
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.
Exportado de SIDERAL (2025-10-17-14:13:11)
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Actinic keratosis (AK) is the main precursor of invasive cutaneous squamous cell carcinoma (cSCC). Since it is impossible to predict which lesions will progress to cSCC, early treatment of AK is crucial. Although AK treatments are effective, some are associated with local skin reactions that may impact treatment compliance and effectiveness. The aim of this modified Delphi study was to review the efficacy and safety of the different AK treatments, gain an understanding of the dermatologists’ perspectives on their use, and provide guidelines for clinical practice.
Materials and methods
This document corresponds to a modified Delphi consensus survey, based on a literature review and a single round of questionnaire.
Results
The Delphi questionnaire was completed by 73 dermatologists from Germany, Italy, and Spain. Agreement was achieved for 78% of statements, while 11% showed discrepancies or were rejected.
Conclusions
Key findings emphasize the importance of patient-centered approaches and treatment attributes beyond efficacy (e.g. tolerability or adherence). Understanding the mechanisms of action of treatments is vital for managing patients’ and clinicians’ expectations and optimizing outcomes. Alternative strategies for evaluating efficacy, including the Actinic Keratosis Area and Severity Index (AKASI) score and lesion reduction from baseline, were also highlighted.
Idioma: Inglés
DOI: 10.1080/09546634.2025.2487657
Año: 2025
Publicado en: JOURNAL OF DERMATOLOGICAL TREATMENT 36, 1 (2025), 2487657 [7 pp.]
ISSN: 0954-6634
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.Exportado de SIDERAL (2025-10-17-14:13:11)
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Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Dermatología
Registro creado el 2025-05-16, última modificación el 2025-10-17