000032208 001__ 32208
000032208 005__ 20210121082905.0
000032208 0247_ $$2doi$$a10.1007/s10439-015-1343-2
000032208 0248_ $$2sideral$$a91011
000032208 037__ $$aART-2015-91011
000032208 041__ $$aeng
000032208 100__ $$0(orcid)0000-0001-7808-381X$$aMoreno-Arotzena, O.
000032208 245__ $$aFibroblast migration in 3D is controlled by haptotaxis in a non-muscle myosin II-dependent manner
000032208 260__ $$c2015
000032208 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032208 5203_ $$aCell migration in 3D is a key process in many physiological and pathological processes. Although valuable knowledge has been accumulated through analysis of various 2D models, some of these insights are not directly applicable to migration in 3D. In this study, we have confined biomimetic hydrogels within microfluidic platforms in the presence of a chemoattractant (platelet-derived growth fac- tor-BB). We have characterized the migratory responses of human fibroblasts within them, particularly focusing on the role of non-muscle myosin II. Our results indicate a prominent role for myosin II in the integration of chemo- tactic and haptotactic migratory responses of fibroblasts in 3D confined environments.
000032208 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2011-24953
000032208 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000032208 590__ $$a2.887$$b2015
000032208 591__ $$aENGINEERING, BIOMEDICAL$$b16 / 76 = 0.211$$c2015$$dQ1$$eT1
000032208 592__ $$a1.2$$b2015
000032208 593__ $$aBiomedical Engineering$$c2015$$dQ1
000032208 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032208 700__ $$0(orcid)0000-0002-3784-1140$$aBorau, C.$$uUniversidad de Zaragoza
000032208 700__ $$0(orcid)0000-0002-0163-8378$$aMovilla, N.
000032208 700__ $$aVicente-Manzanares, M.
000032208 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, J.M.$$uUniversidad de Zaragoza
000032208 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000032208 773__ $$g43, 12 (2015), 3025-3039$$pAnn. biomed. eng.$$tAnnals of Biomedical Engineering$$x0090-6964
000032208 8564_ $$s2958724$$uhttps://zaguan.unizar.es/record/32208/files/texto_completo.pdf$$yVersión publicada
000032208 8564_ $$s95012$$uhttps://zaguan.unizar.es/record/32208/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032208 909CO $$ooai:zaguan.unizar.es:32208$$particulos$$pdriver
000032208 951__ $$a2021-01-21-08:17:39
000032208 980__ $$aARTICLE