000036760 001__ 36760
000036760 005__ 20210121114454.0
000036760 0247_ $$2doi$$a10.1371/journal.pone.0141573
000036760 0248_ $$2sideral$$a93165
000036760 037__ $$aART-2015-93165
000036760 041__ $$aeng
000036760 100__ $$aFerrer, A.
000036760 245__ $$aDetailed anatomical and electrophysiological models of human atria and torso for the simulation of atrial activation
000036760 260__ $$c2015
000036760 5060_ $$aAccess copy available to the general public$$fUnrestricted
000036760 5203_ $$aAtrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics.
000036760 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TIN2014-59932-JIN$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2012-37546-C03-01
000036760 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000036760 590__ $$a3.057$$b2015
000036760 591__ $$aMULTIDISCIPLINARY SCIENCES$$b11 / 62 = 0.177$$c2015$$dQ1$$eT1
000036760 592__ $$a1.427$$b2015
000036760 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000036760 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000036760 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000036760 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000036760 700__ $$aSebastián, R.
000036760 700__ $$aSánchez-Quintana, D.
000036760 700__ $$0(orcid)0000-0001-7612-266X$$aRodríguez, J.F.$$uUniversidad de Zaragoza
000036760 700__ $$aGodoy, E.J.
000036760 700__ $$aMartínez, L.
000036760 700__ $$aSaiz, J.
000036760 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000036760 773__ $$g10, 11 (2015), [29 pp]$$pPLoS One$$tPloS one$$x1932-6203
000036760 8564_ $$s1202388$$uhttps://zaguan.unizar.es/record/36760/files/texto_completo.pdf$$yVersión publicada
000036760 8564_ $$s103878$$uhttps://zaguan.unizar.es/record/36760/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000036760 909CO $$ooai:zaguan.unizar.es:36760$$particulos$$pdriver
000036760 951__ $$a2021-01-21-10:47:18
000036760 980__ $$aARTICLE