000046964 001__ 46964 000046964 005__ 20200221144323.0 000046964 0247_ $$2doi$$a10.1016/j.aca.2015.11.008 000046964 0248_ $$2sideral$$a93056 000046964 037__ $$aART-2016-93056 000046964 041__ $$aeng 000046964 100__ $$0(orcid)0000-0002-4169-0357$$aLaborda, Francisco$$uUniversidad de Zaragoza 000046964 245__ $$aDetection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples 000046964 260__ $$c2016 000046964 5060_ $$aAccess copy available to the general public$$fUnrestricted 000046964 5203_ $$aThe increasing demand of analytical information related to inorganic engineered nanomaterials requires the adaptation of existing techniques and methods, or the development of new ones. The challenge for the analytical sciences has been to consider the nanoparticles as a new sort of analytes, involving both chemical (composition, mass and number concentration) and physical information (e.g. size, shape, aggregation). Moreover, information about the species derived from the nanoparticles themselves and their transformations must also be supplied. Whereas techniques commonly used for nanoparticle characterization, such as light scattering techniques, show serious limitations when applied to complex samples, other well-established techniques, like electron microscopy and atomic spectrometry, can provide useful information in most cases. Furthermore, separation techniques, including flow field flow fractionation, capillary electrophoresis and hydrodynamic chromatography, are moving to the nano domain, mostly hyphenated to inductively coupled plasma mass spectrometry as element specific detector. Emerging techniques based on the detection of single nanoparticles by using ICP-MS, but also coulometry, are in their way to gain a position. Chemical sensors selective to nanoparticles are in their early stages, but they are very promising considering their portability and simplicity. Although the field is in continuous evolution, at this moment it is moving from proofs-of-concept in simple matrices to methods dealing with matrices of higher complexity and relevant analyte concentrations. To achieve this goal, sample preparation methods are essential to manage such complex situations. Apart from size fractionation methods, matrix digestion, extraction and concentration methods capable of preserving the nature of the nanoparticles are being developed. This review presents and discusses the state-of-the-art analytical techniques and sample preparation methods suitable for dealing with complex samples. Single- and multi-method approaches applied to solve the nanometrological challenges posed by a variety of stakeholders are also presented. 000046964 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2012-38091-C02-01 000046964 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000046964 590__ $$a4.95$$b2016 000046964 591__ $$aCHEMISTRY, ANALYTICAL$$b7 / 76 = 0.092$$c2016$$dQ1$$eT1 000046964 592__ $$a1.482$$b2016 000046964 593__ $$aAnalytical Chemistry$$c2016$$dQ1 000046964 593__ $$aSpectroscopy$$c2016$$dQ1 000046964 593__ $$aEnvironmental Chemistry$$c2016$$dQ1 000046964 593__ $$aBiochemistry$$c2016$$dQ1 000046964 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000046964 700__ $$0(orcid)0000-0001-5382-0561$$aBolea, Eduardo$$uUniversidad de Zaragoza 000046964 700__ $$0(orcid)0000-0003-3727-3275$$aCepriá, Gemma$$uUniversidad de Zaragoza 000046964 700__ $$0(orcid)0000-0003-1400-9041$$aGómez, María T.$$uUniversidad de Zaragoza 000046964 700__ $$0(orcid)0000-0002-8460-6020$$aJiménez, María S.$$uUniversidad de Zaragoza 000046964 700__ $$0(orcid)0000-0002-4681-3934$$aPérez-Arantegui, Josefina$$uUniversidad de Zaragoza 000046964 700__ $$0(orcid)0000-0002-4070-8607$$aCastillo, Juan R.$$uUniversidad de Zaragoza 000046964 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000046964 773__ $$g904 (2016), 10-32$$pAnal. chim. acta$$tANALYTICA CHIMICA ACTA$$x0003-2670 000046964 8564_ $$s752510$$uhttps://zaguan.unizar.es/record/46964/files/texto_completo.pdf$$yPostprint 000046964 8564_ $$s68346$$uhttps://zaguan.unizar.es/record/46964/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000046964 909CO $$ooai:zaguan.unizar.es:46964$$particulos$$pdriver 000046964 951__ $$a2020-02-21-13:42:32 000046964 980__ $$aARTICLE