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000047861 0248_ $$2sideral$$a91594
000047861 0247_ $$2doi$$a10.4321/S0213-61632015000100005
000047861 037__ $$aART-2015-91594
000047861 041__ $$aeng
000047861 100__ $$0(orcid)0000-0002-7277-4318$$aMoreno, L.$$uUniversidad de Zaragoza
000047861 245__ $$aNew perspectives in the search for reliable biomarkers in alzheimer disease
000047861 260__ $$c2015
000047861 5060_ $$aAccess copy available to the general public$$fUnrestricted
000047861 5203_ $$aBackground and Objectives: The search for accurate biomarkers in Alzheimer Disease (AD), on of the most devastating neurodegenerative diseases, remains essential to enable an early prognosis and diagnosis of the disease and to provide more efficient ther- apeutic strategies.
A wide variety of potential biomarkers are has been identified by neuroimaging tech- niques and by the analysis of fluid samples, such as cerebrospinal fluid (CSF) or blood. Recently, a growing number of studies are focused on the discovery of reliable blood- based biomarkers in blood, especially in the prodromal stage of AD, which can predict the conversion of asymptomatic cases to AD demented cases.
In this review, the latest challenges in the search for accurate biomarkers of AD is re- vised, in particular, an update in blood-based biomarkers is described in depth.
Conclusions: Finally, the close link among AD and other neurodegenerative diseases is discussed, mainly based on the last discovered mutation, the chromosome 9 open reading frame 72, C9ORF72.
000047861 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI10-0178
000047861 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000047861 590__ $$a0.711$$b2015
000047861 591__ $$aPSYCHIATRY$$b121 / 139 = 0.871$$c2015$$dQ4$$eT3
000047861 592__ $$a0.309$$b2015
000047861 593__ $$aPsychiatry and Mental Health$$c2015$$dQ3
000047861 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000047861 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza
000047861 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, A.C.$$uUniversidad de Zaragoza
000047861 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000047861 773__ $$g29, 1 (2015), 51 - 65$$pEur. j. psychiatry$$tEuropean Journal of Psychiatry$$x0213-6163
000047861 85641 $$uhttp://scielo.isciii.es/scielo.php?pid=S0213-61632015000100005&script=sci_abstract$$zTexto completo de la revista
000047861 8564_ $$s115783$$uhttps://zaguan.unizar.es/record/47861/files/texto_completo.pdf$$yVersión publicada
000047861 8564_ $$s37202$$uhttps://zaguan.unizar.es/record/47861/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000047861 951__ $$a2021-02-08-17:41:51
000047861 980__ $$aARTICLE