New perspectives in the search for reliable biomarkers in alzheimer disease
Moreno, L. (Universidad de Zaragoza) ; Osta, R. (Universidad de Zaragoza) ; Calvo, A.C. (Universidad de Zaragoza)
Resumen: Background and Objectives: The search for accurate biomarkers in Alzheimer Disease (AD), on of the most devastating neurodegenerative diseases, remains essential to enable an early prognosis and diagnosis of the disease and to provide more efficient ther- apeutic strategies.
A wide variety of potential biomarkers are has been identified by neuroimaging tech- niques and by the analysis of fluid samples, such as cerebrospinal fluid (CSF) or blood. Recently, a growing number of studies are focused on the discovery of reliable blood- based biomarkers in blood, especially in the prodromal stage of AD, which can predict the conversion of asymptomatic cases to AD demented cases.
In this review, the latest challenges in the search for accurate biomarkers of AD is re- vised, in particular, an update in blood-based biomarkers is described in depth.
Conclusions: Finally, the close link among AD and other neurodegenerative diseases is discussed, mainly based on the last discovered mutation, the chromosome 9 open reading frame 72, C9ORF72.
Idioma: Inglés
DOI: 10.4321/S0213-61632015000100005
Año: 2015
Publicado en: European Journal of Psychiatry 29, 1 (2015), 51 - 65
ISSN: 0213-6163
Originalmente disponible en: Texto completo de la revista
Factor impacto JCR: 0.711 (2015)
Categ. JCR: PSYCHIATRY rank: 121 / 139 = 0.871 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.309 - Psychiatry and Mental Health (Q3)
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI10-0178
Tipo y forma: Article (Published version)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
Exportado de SIDERAL (2021-02-08-17:41:51)
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A wide variety of potential biomarkers are has been identified by neuroimaging tech- niques and by the analysis of fluid samples, such as cerebrospinal fluid (CSF) or blood. Recently, a growing number of studies are focused on the discovery of reliable blood- based biomarkers in blood, especially in the prodromal stage of AD, which can predict the conversion of asymptomatic cases to AD demented cases.
In this review, the latest challenges in the search for accurate biomarkers of AD is re- vised, in particular, an update in blood-based biomarkers is described in depth.
Conclusions: Finally, the close link among AD and other neurodegenerative diseases is discussed, mainly based on the last discovered mutation, the chromosome 9 open reading frame 72, C9ORF72.
Idioma: Inglés
DOI: 10.4321/S0213-61632015000100005
Año: 2015
Publicado en: European Journal of Psychiatry 29, 1 (2015), 51 - 65
ISSN: 0213-6163
Originalmente disponible en: Texto completo de la revista
Factor impacto JCR: 0.711 (2015)
Categ. JCR: PSYCHIATRY rank: 121 / 139 = 0.871 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.309 - Psychiatry and Mental Health (Q3)
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI10-0178
Tipo y forma: Article (Published version)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. Exportado de SIDERAL (2021-02-08-17:41:51)
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Record created 2016-02-22, last modified 2021-02-08