Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly
Resumen: We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937) on muscle phenotypes (thigh muscles’ cross-sectional, maximal handgrip-strength and 30-second chair stand-test) and Barthel index in Caucasian (Spanish) community-dwelling old people (n=75, 21 men, 54 women; 71–94 years). We found no significant genetic associations with the studied phenotypes. Multiple, com- plex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role.
Idioma: Inglés
DOI: 10.5232/ricyde2015.04101
Año: 2015
Publicado en: Revista internacional de ciencias del deporte 11, 41 (2015), 196-208
ISSN: 1885-3137

Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/MINECO/FIS/PI09-00194
Tipo y forma: Article (Published version)
Área (Departamento): Educación Física y Deportiva (Departamento de Fisiatría y Enfermería)

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