New insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS.

Luesma MJ (Universidad de Zaragoza) ; Cantarero I ; Álvarez-Dotu JM (Universidad de Zaragoza) ; Santander S (Universidad de Zaragoza) ; Junquera C. (Universidad de Zaragoza)
New insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS.
Resumen: The receptor tyrosine kinase Ret (c-Ret) transduces the glial cell line-derived neurotrophic factor (GDNF) signal, one of the neurotrophic factors related to the degeneration process or the regeneration activity of motor neurons in amyotrophic lateral sclerosis (ALS). The phosphorylation of several tyrosine residues of c-Ret seems to be altered in ALS. c-Ret is expressed in motor neurons and in the enteric nervous system (ENS) during the embryonic period. The characteristics of the ENS allow using it as model for central nervous system (CNS) study and being potentially useful for the research of human neurological diseases such as ALS. The aim of the present study was to investigate the cellular localization and quantitative evaluation of marker c-Ret in the adult human gut. To assess the nature of c-Ret positive cells, we performed colocalization with specific markers of cells that typically are located in the enteric ganglia. The colocalization of PGP9.5 and c-Ret was preferentially intense in enteric neurons with oval morphology and mostly peripherally localized in the ganglion, so we concluded that the c-Ret receptor is expressed by a specific subtype of enteric neurons in the mature human ENS of the gut. The functional significance of these c-Ret positive neurons is discussed.
Idioma: Inglés
DOI: 10.1155/2014/328348
Año: 2014
Publicado en: BioMed Research International 2014 (2014), 328348 [7 p.]
ISSN: 2314-6133

Factor impacto JCR: 1.579 (2014)
Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 85 / 123 = 0.691 (2014) - Q3 - T3
Categ. JCR: BIOTECHNOLOGY & APPLIED MICROBIOLOGY rank: 106 / 162 = 0.654 (2014) - Q3 - T2

Factor impacto SCIMAGO:

Tipo y forma: Article (Published version)
Área (Departamento): Estomatología (Departamento de Cirugía, Ginecología y Obstetricia)
Área (Departamento): Histología (Departamento de Anatomía e Histología Humanas)
Área (Departamento): Farmacología (Departamento de Farmacología y Fisiología)
Área (Departamento): Anatomía y Embriología Humana (Departamento de Anatomía e Histología Humanas)


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Exportado de SIDERAL (2016-04-14-11:50:25)

Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Anatomía y Embriología Humana
Articles > Artículos por área > Estomatología
Articles > Artículos por área > Farmacología
Articles > Artículos por área > Histología



 Record created 2016-04-14, last modified 2017-03-27


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