000048724 001__ 48724
000048724 005__ 20200221144309.0
000048724 0247_ $$2doi$$a10.1016/j.bjm.2016.01.029
000048724 0248_ $$2sideral$$a94839
000048724 037__ $$aART-2016-94839
000048724 041__ $$aeng
000048724 100__ $$0(orcid)0000-0003-0029-4822$$aBetrán Escartín, Ana$$uUniversidad de Zaragoza
000048724 245__ $$aClinical significance, antimicrobial susceptibility and molecular identification of Nocardia species isolated from children with cystic fibrosis
000048724 260__ $$c2016
000048724 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048724 5203_ $$aNocardia is an opportunistic pathogen that causes respiratory infections in immunocompromised patients. The aim of this study was to analyze the epidemiology, clinical significance and antimicrobial susceptibility of Nocardia species isolated from eight children with cystic fibrosis. The isolated species were identified as Nocardia farcinica, Nocardia transvalensis, Nocardia pneumoniae, Nocardia veterana and Nocardia wallacei. N. farcinica was isolated in three patients and all of them presented lung affectation with a chronic colonization and pneumonia. N. farcinica showed resistance against gentamicin, tobramycin, cefotaxime, but was susceptible to trimethoprim-sulfamethoxazole and amikacin. N. transvalensis, which was isolated from two patients, showed an association with chronic colonization. N. transvalensis was resistant to tobramycin and amikacin, but susceptible to ciprofloxacin, trimethoprim-sulfamethoxazole and cefotaxime. N. veterana, N. pneumoniae and N. wallacei were isolated from three different patients and appeared in transitory lung colonization. N. veterana and N. pneumoniae were susceptible to imipenem, trimethoprim-sulfamethoxazole, amikacin, tobramycin, and cefotaxime. N. wallacei was resistant to amikacin, tobramycin, imipenem, and trimethoprim-sulfamethoxazole and susceptible to ciprofloxacin and cefotaxime. All the isolates were identified up to species level by 16S rRNA gene sequencing. The presence of Nocardia in the sputum of patients with cystic fibrosis is not always an indication of an active infection; therefore, the need for a treatment should be evaluated on an individual basis. The detection of multidrug-resistant species needs molecular identification and susceptibility testing, and should be performed for all Nocardia infections.
000048724 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000048724 590__ $$a1.091$$b2016
000048724 591__ $$aMICROBIOLOGY$$b107 / 124 = 0.863$$c2016$$dQ4$$eT3
000048724 592__ $$a0.493$$b2016
000048724 593__ $$aMicrobiology$$c2016$$dQ3
000048724 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000048724 700__ $$aVilluendas, Mª Cruz
000048724 700__ $$0(orcid)0000-0001-7294-245X$$aRezusta, Antonio$$uUniversidad de Zaragoza
000048724 700__ $$aPereira, Javier
000048724 700__ $$0(orcid)0000-0003-3570-5791$$aRevillo, Mª José
000048724 700__ $$aRodríguez-Nava, Verónica
000048724 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000048724 773__ $$g47, 3 (2016), 531–535$$pBRAZ J MICROBIOL$$tBRAZILIAN JOURNAL OF MICROBIOLOGY$$x1517-8382
000048724 8564_ $$s549051$$uhttps://zaguan.unizar.es/record/48724/files/texto_completo.pdf$$yVersión publicada
000048724 8564_ $$s19343$$uhttps://zaguan.unizar.es/record/48724/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048724 909CO $$ooai:zaguan.unizar.es:48724$$particulos$$pdriver
000048724 951__ $$a2020-02-21-13:36:24
000048724 980__ $$aARTICLE