A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study
Gimeno, M. ; Pinczowski, P. ; Pérez, M. (Universidad de Zaragoza) ; Giorello, A. ; Martínez, M.Á. (Universidad de Zaragoza) ; Santamaría, J. (Universidad de Zaragoza) ; Arruebo, M. (Universidad de Zaragoza) ; Luján, L. (Universidad de Zaragoza)
Resumen: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.
Idioma: Inglés
DOI: 10.1016/j.ejpb.2015.08.007
Año: 2015
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics 96 (2015), 264-271
ISSN: 0939-6411
Factor impacto JCR: 3.975 (2015)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 44 / 255 = 0.173 (2015) - Q1 - T1
Factor impacto SCIMAGO: 1.437 - Biotechnology (Q1) - Pharmaceutical Science (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma: Article (Published version)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2021-01-21-10:50:10)
Visitas y descargas
Idioma: Inglés
DOI: 10.1016/j.ejpb.2015.08.007
Año: 2015
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics 96 (2015), 264-271
ISSN: 0939-6411
Factor impacto JCR: 3.975 (2015)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 44 / 255 = 0.173 (2015) - Q1 - T1
Factor impacto SCIMAGO: 1.437 - Biotechnology (Q1) - Pharmaceutical Science (Q1) - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma: Article (Published version)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2021-01-21-10:50:10)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles
Record created 2016-07-12, last modified 2021-01-21