000056361 001__ 56361
000056361 005__ 20200221144306.0
000056361 0247_ $$2doi$$a10.1093/infdis/jiv503
000056361 0248_ $$2sideral$$a93909
000056361 037__ $$aART-2016-93909
000056361 041__ $$aeng
000056361 100__ $$0(orcid)0000-0001-7897-9173$$aAguiló, N$$uUniversidad de Zaragoza
000056361 245__ $$aPulmonary but not subcutaneous vaccination confers protection to TB susceptible mice by an IL17-dependent mechanism.
000056361 260__ $$c2016
000056361 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056361 5203_ $$aSome of the most promising novel tuberculosis vaccine strategies currently under development are based on respiratory vaccination, mimicking the natural route of infection. In this work, we have compared pulmonary and subcutaneous delivery of BCG vaccine in the tuberculosis-susceptible DBA/2 mouse strain, a model in which parenterally administered BCG vaccine does not protect against tuberculosis. Our data show that intranasally but not subcutaneously administered BCG confers robust protection against pulmonary tuberculosis challenge. In addition, our results indicate that pulmonary vaccination triggers a Mycobacterium tuberculosis–specific mucosal immune response orchestrated by interleukin 17A (IL-17A). Thus, IL-17A neutralization in vivo reduces protection and abrogates M. tuberculosis–specific immunoglobulin A (IgA) secretion to respiratory airways and lung expression of polymeric immunoglobulin receptor induced following intranasal vaccination. Together, our results demonstrate that pulmonary delivery of BCG can overcome the lack of protection observed when BCG is given parenterally, suggesting that respiratory tuberculosis vaccines could have an advantage in tuberculosis-endemic countries, where intradermally administered BCG has inefficient effectiveness against pulmonary tuberculosis.
000056361 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BIO2014-5258P$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643381-TBVAC2020$$9info:eu-repo/grantAgreement/EC/H2020/643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020
000056361 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000056361 590__ $$a6.273$$b2016
000056361 591__ $$aIMMUNOLOGY$$b23 / 150 = 0.153$$c2016$$dQ1$$eT1
000056361 591__ $$aMICROBIOLOGY$$b15 / 124 = 0.121$$c2016$$dQ1$$eT1
000056361 591__ $$aINFECTIOUS DISEASES$$b7 / 84 = 0.083$$c2016$$dQ1$$eT1
000056361 592__ $$a3.931$$b2016
000056361 593__ $$aInfectious Diseases$$c2016$$dQ1
000056361 593__ $$aImmunology and Allergy$$c2016$$dQ1
000056361 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000056361 700__ $$0(orcid)0000-0002-5748-6078$$aÁlvarez-Arguedas, S$$uUniversidad de Zaragoza
000056361 700__ $$0(orcid)0000-0001-7866-2803$$aUranga, S$$uUniversidad de Zaragoza
000056361 700__ $$0(orcid)0000-0001-8644-120X$$aMarinova, D$$uUniversidad de Zaragoza
000056361 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, M$$uUniversidad de Zaragoza
000056361 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J$$uUniversidad de Zaragoza
000056361 700__ $$0(orcid)0000-0003-2993-5478$$aMartín, C$$uUniversidad de Zaragoza
000056361 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000056361 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000056361 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000056361 7102_ $$11008$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cProy. investigación HQA
000056361 773__ $$g213, 5 (2016), 831-839$$pJ. infect. dis.$$tJOURNAL OF INFECTIOUS DISEASES$$x0022-1899
000056361 8564_ $$s1642484$$uhttps://zaguan.unizar.es/record/56361/files/texto_completo.pdf$$yPostprint
000056361 8564_ $$s48552$$uhttps://zaguan.unizar.es/record/56361/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000056361 909CO $$ooai:zaguan.unizar.es:56361$$particulos$$pdriver
000056361 951__ $$a2020-02-21-13:34:46
000056361 980__ $$aARTICLE