000056822 001__ 56822 000056822 005__ 20200221144308.0 000056822 0247_ $$2doi$$a10.3390/molecules21091141 000056822 0248_ $$2sideral$$a96399 000056822 037__ $$aART-2016-96399 000056822 041__ $$aeng 000056822 100__ $$aViveros-Ceballos, J. 000056822 245__ $$aStereoselective synthesis of a-Amino-C-phosphinic acids and derivatives 000056822 260__ $$c2016 000056822 5060_ $$aAccess copy available to the general public$$fUnrestricted 000056822 5203_ $$aa-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have acquired pharmacological importance in influencing physiologic and pathologic processes, primarily acting as inhibitors for proteolytic enzymes where molecular stereochemistry has proven to be critical. This review summarizes the latest developments in the asymmetric synthesis of acyclic and phosphacyclic a-amino-C-phosphinic acids and derivatives, following in the first case an order according to the strategy used, whereas for cyclic compounds the nitrogen embedding in the heterocyclic core is considered. In addition selected examples of pharmacological implications of title compounds are also disclosed. 000056822 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2013-40855-R$$9info:eu-repo/grantAgreement/ES/DGA/E40 000056822 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000056822 590__ $$a2.861$$b2016 000056822 591__ $$aCHEMISTRY, ORGANIC$$b17 / 59 = 0.288$$c2016$$dQ2$$eT1 000056822 592__ $$a0.824$$b2016 000056822 593__ $$aAnalytical Chemistry$$c2016$$dQ1 000056822 593__ $$aPharmaceutical Science$$c2016$$dQ1 000056822 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1 000056822 593__ $$aOrganic Chemistry$$c2016$$dQ2 000056822 593__ $$aPhysical and Theoretical Chemistry$$c2016$$dQ2 000056822 593__ $$aDrug Discovery$$c2016$$dQ2 000056822 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2 000056822 593__ $$aMolecular Medicine$$c2016$$dQ3 000056822 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000056822 700__ $$aOrdóñez, M. 000056822 700__ $$0(orcid)0000-0001-5652-5170$$aSayago, F.J.$$uUniversidad de Zaragoza 000056822 700__ $$0(orcid)0000-0003-3222-0828$$aCativiela, C.$$uUniversidad de Zaragoza 000056822 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000056822 773__ $$g21, 9 (2016), E1141 [31 pp]$$pMolecules$$tMolecules$$x1420-3049 000056822 8564_ $$s11204812$$uhttps://zaguan.unizar.es/record/56822/files/texto_completo.pdf$$yVersión publicada 000056822 8564_ $$s91805$$uhttps://zaguan.unizar.es/record/56822/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000056822 909CO $$ooai:zaguan.unizar.es:56822$$particulos$$pdriver 000056822 951__ $$a2020-02-21-13:36:09 000056822 980__ $$aARTICLE