000057085 001__ 57085
000057085 005__ 20200221144254.0
000057085 0247_ $$2doi$$a10.1371/journal.pone.0160770
000057085 0248_ $$2sideral$$a96631
000057085 037__ $$aART-2016-96631
000057085 041__ $$aeng
000057085 100__ $$aCosio, B.G.
000057085 245__ $$aDistribution and outcomes of a phenotype-based approach to guide COPD management: Results from the CHAIN cohort
000057085 260__ $$c2016
000057085 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057085 5203_ $$aRationale: The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. Objective: We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. Methods: We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Results: Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p<0.05). The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05 compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05) with no differences in one-year mortality. Most of NE (93%) and half of exacerbators were stable after one year. Conclusions: There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use.
000057085 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057085 590__ $$a2.806$$b2016
000057085 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000057085 592__ $$a1.236$$b2016
000057085 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000057085 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057085 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000057085 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057085 700__ $$aSoriano, J.B.
000057085 700__ $$aLópez-Campos, J.L.
000057085 700__ $$aCalle, M.
000057085 700__ $$aSoler, J.J.
000057085 700__ $$aDe-Torres, J.
000057085 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, J.M.$$uUniversidad de Zaragoza
000057085 700__ $$aMartínez, C.
000057085 700__ $$aDe Lucas, P.
000057085 700__ $$aMir, I.
000057085 700__ $$aPeces-Barba, G.
000057085 700__ $$aFeu-Collado, N.
000057085 700__ $$aSolanes, I.
000057085 700__ $$aAlfageme, I.
000057085 700__ $$aBonachera, J.C.
000057085 700__ $$aBautista, C.L.
000057085 700__ $$aDomenech, A.
000057085 700__ $$aGuzmán, R.
000057085 700__ $$aIrigaray, R.
000057085 700__ $$aZamora, M.L.
000057085 700__ $$aRíos, A.
000057085 700__ $$aCórdova, R.
000057085 700__ $$aViladrich, I.M.
000057085 700__ $$aLópez, C.C.
000057085 700__ $$aAcosta, A.S.
000057085 700__ $$aGonzález, J.A.
000057085 700__ $$aBalbin, R.A.
000057085 700__ $$aBalcells, E.
000057085 700__ $$aCampos, E.M.
000057085 700__ $$aMarin, A.
000057085 700__ $$aCasanova, A.L.
000057085 700__ $$aMoreno, A.
000057085 700__ $$aPérez, F.L.M.
000057085 700__ $$aMiranda, J.A.R.
000057085 700__ $$aRodríguez, J.T.
000057085 700__ $$aGómez, R.G.
000057085 700__ $$aDe, Miguel D.
000057085 700__ $$aRío, F.G.
000057085 700__ $$aLobato, S.D.
000057085 700__ $$aIturri, J.B.G.
000057085 700__ $$aRoyo, M.M.
000057085 700__ $$aDe, Diego Damia
000057085 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000057085 773__ $$g11, 9 (2016), 0160770 [15 pp]$$pPLoS One$$tPloS one$$x1932-6203
000057085 8564_ $$s1634537$$uhttps://zaguan.unizar.es/record/57085/files/texto_completo.pdf$$yVersión publicada
000057085 8564_ $$s98554$$uhttps://zaguan.unizar.es/record/57085/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057085 909CO $$ooai:zaguan.unizar.es:57085$$particulos$$pdriver
000057085 951__ $$a2020-02-21-13:29:04
000057085 980__ $$aARTICLE