000057913 001__ 57913 000057913 005__ 20201023135900.0 000057913 0247_ $$2doi$$a10.1155/2014/925101 000057913 0248_ $$2sideral$$a87873 000057913 037__ $$aART-2014-87873 000057913 041__ $$aeng 000057913 100__ $$0(orcid)0000-0001-5193-7782$$aCalvo Royo, Ana Cristina$$uUniversidad de Zaragoza 000057913 245__ $$aAmyotrophic Lateral Sclerosis: A Focus on Disease Progression 000057913 260__ $$c2014 000057913 5060_ $$aAccess copy available to the general public$$fUnrestricted 000057913 5203_ $$aSince amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However, the molecular targets that directly influence its aggressive nature remain unknown.What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives. 000057913 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI10-0178$$9info:eu-repo/grantAgreement/ES/UZ/UZ2012-BIO-02-210-155 000057913 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000057913 590__ $$a1.579$$b2014 000057913 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b85 / 123 = 0.691$$c2014$$dQ3$$eT3 000057913 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b107 / 163 = 0.656$$c2014$$dQ3$$eT2 000057913 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000057913 700__ $$aManzano, Raquel 000057913 700__ $$aMendonça, Deise M.F. 000057913 700__ $$aMuñoz, María Jesús 000057913 700__ $$aZaragoza, Pilar 000057913 700__ $$aOsta, Rosario 000057913 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000057913 773__ $$g2014 (2014), 925101 [12 pp]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133 000057913 8564_ $$s762433$$uhttps://zaguan.unizar.es/record/57913/files/texto_completo.pdf$$yVersión publicada 000057913 8564_ $$s101985$$uhttps://zaguan.unizar.es/record/57913/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000057913 909CO $$ooai:zaguan.unizar.es:57913$$particulos$$pdriver 000057913 951__ $$a2020-10-23-13:53:36 000057913 980__ $$aARTICLE