000058479 001__ 58479
000058479 005__ 20200221144337.0
000058479 0247_ $$2doi$$a10.1186/s13601-016-0114-y
000058479 0248_ $$2sideral$$a97591
000058479 037__ $$aART-2016-97591
000058479 041__ $$aeng
000058479 100__ $$aSegura, N.
000058479 245__ $$aInfluence of profilin on sensitisation profiles determined by cutaneous tests and IgE to major allergens in polysensitised patients
000058479 260__ $$c2016
000058479 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058479 5203_ $$aBackground: Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and children and to evaluate, by means of component-resolved diagnosis (CRD) and skin prick testing (SPT), which pollens may be considered as risk factors of profilin sensitisation in order to establish the best diagnostic approach in polysensitised patients. Methods: A total of 231 pollen-allergic patients (adults and children) were included, out of the pollen season, from an area with similar levels of pollen exposure. Allergological diagnosis was performed by SPT and determination of specific IgE (sIgE) to major allergen components (ADVIA-Centaur™). Patients had not received immunotherapy in the last 5 years and had to reside in the area for 5 consecutive years before entering the study. Results: The relation between sensitisation measured by SPT and by sIgE was studied using a model of cases (patients with +sIgE to a specific allergen) and controls (patients with -sIgE to the same allergen). The outcome, in terms of odds-ratios (OR), was statistically significant for Olea (Ole e 1) (p = 0.0005), Salsola (Sal k 1) (p = 0.0118) and Platanus (Pla a 1+ 2) (p = 0.0372). While positivity of SPT to most pollens was statistically associated with a risk of profilin sensitisation, by CRD the association was statistically significant only for Ole e 1 (OR 3.5, CI 95 %, 1.6-7.6, p = 0.0014), and Phl p 5 (OR 11.9, CI 95 %, 4.1-35.2, p < 0.001). When analysing this association using a logistic regression model, Phl p 5 was the only allergen associated with the risk of being sensitised to profilin (p = 0.0023). Conclusions: In patients sensitised to profilin, the concordance between SPT and CRD is much lower than in those not sensitised to profilin. CRD is able to provide refined information about which pollens increase the risk of sensitisation to profilin.
000058479 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000058479 590__ $$a3.239$$b2016
000058479 591__ $$aALLERGY$$b12 / 26 = 0.462$$c2016$$dQ2$$eT2
000058479 592__ $$a1.139$$b2016
000058479 593__ $$aImmunology and Allergy$$c2016$$dQ2
000058479 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000058479 700__ $$aAbos, T.
000058479 700__ $$aCompaired, J.A.
000058479 700__ $$aCompés, E.
000058479 700__ $$aGuallar, I.
000058479 700__ $$aMorales, M.
000058479 700__ $$aMonzón, S.
000058479 700__ $$0(orcid)0000-0002-2575-2837$$aMozota, J.$$uUniversidad de Zaragoza
000058479 700__ $$aMuñoz, P.
000058479 700__ $$aPola, J.
000058479 700__ $$aQuintana, M.
000058479 700__ $$aRojas, B.
000058479 700__ $$aJuan, S.S.
000058479 700__ $$aVilla, F.
000058479 700__ $$aZapata, C.
000058479 700__ $$aJimeno, L.
000058479 700__ $$aDe La Torre, F.
000058479 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000058479 773__ $$g6, 1 (2016), 23 [7 pp]$$pClin. transl. allergy$$tClinical and translational allergy$$x2045-7022
000058479 8564_ $$s1070344$$uhttps://zaguan.unizar.es/record/58479/files/texto_completo.pdf$$yVersión publicada
000058479 8564_ $$s104468$$uhttps://zaguan.unizar.es/record/58479/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000058479 909CO $$ooai:zaguan.unizar.es:58479$$particulos$$pdriver
000058479 951__ $$a2020-02-21-13:48:10
000058479 980__ $$aARTICLE