Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids

Keller, L. ; Idoux-Gillet, Y. ; Wagner, Q. ; Eap, S. ; Brasse, D. ; Schwinté, P. ; Arruebo, M. (Universidad de Zaragoza) ; Benkirane-Jessel, N.

Resumen: In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants.

Idioma: Inglés

DOI: 10.2147/IJN.S116749

Año: 2017

Publicado en: International Journal of Nanomedicine 12 (2017), 447-457
ISSN: 1176-9114

Factor impacto JCR: 4.37 (2017)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 31 / 261 = 0.119 (2017) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 35 / 92 = 0.38 (2017) - Q2 - T2

Factor impacto SCIMAGO: 1.225 - Bioengineering (Q1) - Biomaterials (Q1) - Biophysics (Q1) - Organic Chemistry (Q1) - Medicine (miscellaneous) (Q1) - Drug Discovery (Q1) - Nanoscience and Nanotechnology (Q2)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)