000060716 001__ 60716
000060716 005__ 20190709135449.0
000060716 0247_ $$2doi$$a10.2147/OPTH.S125203
000060716 0248_ $$2sideral$$a98180
000060716 037__ $$aART-2017-98180
000060716 041__ $$aeng
000060716 100__ $$aMateo Orobia, A.J.
000060716 245__ $$aEffects of 3% trehalose as an adjuvant treatment after lasik
000060716 260__ $$c2017
000060716 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060716 5203_ $$aPurpose: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis. Design: Interventional prospective comparative single-blind study. Setting: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain. Methods: A total of 26 eyes (13 patients) were included, of which 12 eyes (group 1) received conventional treatment with lubricant drops of hyaluronic acid (0.15%) and 14 eyes (group 2) received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made. Results: We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001), and in the National Eye Institute scale in day 30 (P=0.02). Conclusion: The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality.
000060716 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000060716 592__ $$a1.035$$b2017
000060716 593__ $$aOphthalmology$$c2017$$dQ2
000060716 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060716 700__ $$aCasas Pascual, P.
000060716 700__ $$aCristóbal Bescós, J.Á.
000060716 700__ $$aPerez García, D.
000060716 700__ $$aPeiro Embid, C.
000060716 700__ $$0(orcid)0000-0002-9325-9964$$aDel Buey Sayas, M.A.$$uUniversidad de Zaragoza
000060716 700__ $$aKorobko Kulikova, V.
000060716 700__ $$aMateo Ojeda, N.
000060716 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000060716 773__ $$g11 (2017), 347-353$$pClin. Ophthalmol.$$tClinical Ophthalmology$$x1177-5467
000060716 8564_ $$s631046$$uhttp://zaguan.unizar.es/record/60716/files/texto_completo.pdf$$yVersión publicada
000060716 8564_ $$s59308$$uhttp://zaguan.unizar.es/record/60716/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060716 909CO $$ooai:zaguan.unizar.es:60716$$particulos$$pdriver
000060716 951__ $$a2019-07-09-11:39:39
000060716 980__ $$aARTICLE