000060818 001__ 60818
000060818 005__ 20170323124744.0
000060818 037__ $$aTAZ-TFG-2016-1895
000060818 041__ $$aspa
000060818 1001_ $$aRoyo Pérez, Víctor
000060818 24200 $$aFinite Element simulation of cellular deformation in confinement environments
000060818 24500 $$aSimulación por elementos finitos de la deformación celular en ambientes confinados
000060818 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2016
000060818 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000060818 520__ $$aCell migration has gained attention over the last years due to its key role in different physiological and pathological process such as embryonic development and tumour growth. Many researchers have developed studies about what stimulate the cells and the critical point in the cell mobility. In this work, we consider cell migration in microchannels, simulating the moment when the cell cross extravase to the veins. Since the tool for elaborating that is the commercial software ABAQUS, a model with an axisymmetric Walker 256 carcinosarcoma cell with Neo-Hookean hyperelastic material and a rigid tube is described. In order to do that, two different parts are considered in the cell, membrane and nucleus, both clearly identify with different properties and features. As a result of the model presented, we found that not only the fluid drag and friction help to the cellular motion, but internal and biological aspects not developed before like the contraction of myosin and mainly, the protrusion of the actin affect strongly to the cell motility. A mathematical analysis, backed by the numerical simulations of cellular deformation, indicates that polymerization phenomenon and contractility play an important role in enabling cells to modify the external shape and let them moving towards for the migration direction.
000060818 521__ $$aGraduado en Ingeniería Mecánica
000060818 540__ $$aDerechos regulados por licencia Creative Commons
000060818 700__ $$aGarcía Aznar, José Manuel$$edir.
000060818 700__ $$aGómez Benito, Mª José$$edir.
000060818 7102_ $$aUniversidad de Zaragoza$$bIngeniería Mecánica$$cMec. de Medios Contínuos y Teor. de Estructuras
000060818 8560_ $$f666683@celes.unizar.es
000060818 8564_ $$s1718290$$uhttps://zaguan.unizar.es/record/60818/files/TAZ-TFG-2016-1895.pdf$$yMemoria (spa)
000060818 909CO $$ooai:zaguan.unizar.es:60818$$pdriver$$ptrabajos-fin-grado
000060818 950__ $$a
000060818 951__ $$adeposita:2017-03-23
000060818 980__ $$aTAZ$$bTFG$$cEINA