Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue

Waffenschmidt, T. ; Cilla, M. ; Sáez, P. ; Pérez, M.M. ; Martínez, M.A. (Universidad de Zaragoza) ; Menzel, A. ; Peña, E. (Universidad de Zaragoza)

Resumen: The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE-/- and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE-/- mice aortas exhibit a saturation-type increase with respect to age.

Idioma: Inglés

DOI: 10.1016/j.jbiomech.2016.01.043

Año: 2016

Publicado en: Journal of Biomechanics 49, 12 (2016), 2390-2397
ISSN: 0021-9290

Factor impacto JCR: 2.664 (2016)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 25 / 77 = 0.325 (2016) - Q2 - T1
Categ. JCR: BIOPHYSICS rank: 32 / 73 = 0.438 (2016) - Q2 - T2

Factor impacto SCIMAGO: 1.242 - Biomedical Engineering (Q1) - Biophysics (Q1) - Sports Science (Q1) - Rehabilitation (Q1) - Orthopedics and Sports Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/T88
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PRI-AIBDE-2011-1216

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)