000060889 001__ 60889
000060889 005__ 20170330113833.0
000060889 0247_ $$2doi$$a10.1128/JCM.00970-13
000060889 0248_ $$2sideral$$a84166
000060889 037__ $$aART-2013-84166
000060889 041__ $$aeng
000060889 100__ $$aMillan-Lou, M.I.
000060889 245__ $$aGlobal study of is6110 in a successful mycobacterium tuberculosis strain: Clues for deciphering its behavior and for its rapid detection
000060889 260__ $$c2013
000060889 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060889 5203_ $$aThe Mycobacterium tuberculosis insertion sequence IS6110, besides being a very useful tool in molecular epidemiology, seems to have an impact on the biology of bacilli. In the present work, we mapped the 12 points of insertion of IS6110 in the genome of a successful strain named M. tuberculosis Zaragoza (which has been referred to as the MTZ strain). This strain, belonging to principal genetic group 3, caused a large unsuspected tuberculosis outbreak involving 85 patients in Zaragoza, Spain, in 2001 to 2004. The mapping of the points of insertion of IS6110 in the genome of the Zaragoza strain offers clues for a better understanding of the adaptability and virulence of M. tuberculosis. Surprisingly, the presence of one copy of IS6110 was found in Rv2286c, as was recently described for a successful Beijing sublineage. As a result of this analysis, a rapid method for detecting this particular M. tuberculosis strain has been designed.
000060889 536__ $$9info:eu-repo/grantAgreement/ES/FIS/FIS09-051$$9info:eu-repo/grantAgreement/ES/FIS/FIS12/1970$$9info:eu-repo/grantAgreement/ES/ISCIII/CM09-000123
000060889 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000060889 590__ $$a4.232$$b2013
000060889 591__ $$aMICROBIOLOGY$$b23 / 118 = 0.195$$c2013$$dQ1$$eT1
000060889 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060889 700__ $$aLópez-Calleja, A.I.
000060889 700__ $$aColmenarejo, C.
000060889 700__ $$aLezcano, M.A.
000060889 700__ $$0(orcid)0000-0003-4198-6622$$aVitoria, M.A.$$uUniversidad de Zaragoza
000060889 700__ $$aDel Portillo, P.
000060889 700__ $$0(orcid)0000-0003-1027-7583$$aOtal, I.$$uUniversidad de Zaragoza
000060889 700__ $$aMartín, C.
000060889 700__ $$0(orcid)0000-0002-3011-2519$$aSamper, S.
000060889 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMicrobiología
000060889 773__ $$g51, 11 (2013), 3631-3637$$pJ. clin. microbiol.$$tJOURNAL OF CLINICAL MICROBIOLOGY$$x0095-1137
000060889 8564_ $$s451553$$uhttps://zaguan.unizar.es/record/60889/files/texto_completo.pdf$$yVersión publicada
000060889 8564_ $$s53822$$uhttps://zaguan.unizar.es/record/60889/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060889 909CO $$ooai:zaguan.unizar.es:60889$$particulos$$pdriver
000060889 951__ $$a2017-03-29-12:05:50
000060889 980__ $$aARTICLE