000060929 001__ 60929
000060929 005__ 20200221144153.0
000060929 0247_ $$2doi$$a10.1016/j.cmpb.2016.04.006
000060929 0248_ $$2sideral$$a94667
000060929 037__ $$aART-2016-94667
000060929 041__ $$aeng
000060929 100__ $$0(orcid)0000-0003-2378-7187$$aLópez,E.$$uUniversidad de Zaragoza
000060929 245__ $$aA predictive mechanical model for evaluating vertebral fracture probability in lumbar spine under different osteoporotic drug therapies
000060929 260__ $$c2016
000060929 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060929 5203_ $$aOsteoporotic vertebral fractures represent a major cause of disability, loss of quality of life and even mortality among the elderly population. Decisions on drug therapy are based on the assessment of risk factors for fracture from bone mineral density (BMD) measurements.A previously developed model, based on the Damage and Fracture Mechanics, was applied for the evaluation of the mechanical magnitudes involved in the fracture process from clinical BMD measurements. BMD evolution in untreated patients and in patients with seven different treatments was analyzed from clinical studies in order to compare the variation in the risk of fracture. The predictive model was applied in a finite element simulation of the whole lumbar spine, obtaining detailed maps of damage and fracture probability, identifying high-risk local zones at vertebral body.For every vertebra, strontium ranelate exhibits the highest decrease, whereas minimum decrease is achieved with oral ibandronate. All the treatments manifest similar trends for every vertebra. Conversely, for the natural BMD evolution, as bone stiffness decreases, the mechanical damage and fracture probability show a significant increase (as it occurs in the natural history of BMD). Vertebral walls and external areas of vertebral end plates are the zones at greatest risk, in coincidence with the typical locations of osteoporotic fractures, characterized by a vertebral crushing due to the collapse of vertebral walls.This methodology could be applied for an individual patient, in order to obtain the trends corresponding to different treatments, in identifying at-risk individuals in early stages of osteoporosis and might be helpful for treatment decisions.
000060929 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000060929 590__ $$a2.503$$b2016
000060929 591__ $$aCOMPUTER SCIENCE, THEORY & METHODS$$b21 / 104 = 0.202$$c2016$$dQ1$$eT1
000060929 591__ $$aMEDICAL INFORMATICS$$b8 / 23 = 0.348$$c2016$$dQ2$$eT2
000060929 591__ $$aENGINEERING, BIOMEDICAL$$b26 / 77 = 0.338$$c2016$$dQ2$$eT2
000060929 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b32 / 105 = 0.305$$c2016$$dQ2$$eT1
000060929 592__ $$a0.639$$b2016
000060929 593__ $$aComputer Science Applications$$c2016$$dQ2
000060929 593__ $$aSoftware$$c2016$$dQ2
000060929 593__ $$aHealth Informatics$$c2016$$dQ2
000060929 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000060929 700__ $$0(orcid)0000-0003-0785-4132$$aIbarz,E.$$uUniversidad de Zaragoza
000060929 700__ $$0(orcid)0000-0002-8643-7558$$aHerrera,A.$$uUniversidad de Zaragoza
000060929 700__ $$0(orcid)0000-0002-3613-4209$$aPuértolas,S.$$uUniversidad de Zaragoza
000060929 700__ $$0(orcid)0000-0002-2934-1525$$aGabarre,S.
000060929 700__ $$aMás,Y.
000060929 700__ $$0(orcid)0000-0001-7516-4737$$aMateo,J.$$uUniversidad de Zaragoza
000060929 700__ $$0(orcid)0000-0002-1563-9136$$aGil-Albarova,J.$$uUniversidad de Zaragoza
000060929 700__ $$0(orcid)0000-0001-7944-9625$$aGracia,L.$$uUniversidad de Zaragoza
000060929 7102_ $$11004$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Traumatología y Ortopedia
000060929 7102_ $$15002$$2305$$aUniversidad de Zaragoza$$bDpto. Ingeniería Diseño Fabri.$$cÁrea Expresión Gráfica en Ing.
000060929 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000060929 773__ $$g131 (2016), 37-50$$pComput. methods programs biomed.$$tComputer Methods and Programs in Biomedicine$$x0169-2607
000060929 8564_ $$s993830$$uhttps://zaguan.unizar.es/record/60929/files/texto_completo.pdf$$yPostprint
000060929 8564_ $$s76536$$uhttps://zaguan.unizar.es/record/60929/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000060929 909CO $$ooai:zaguan.unizar.es:60929$$particulos$$pdriver
000060929 951__ $$a2020-02-21-13:08:00
000060929 980__ $$aARTICLE