Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins
Resumen: New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.
Idioma: Inglés
DOI: 10.3762/bjoc.13.59
Año: 2017
Publicado en: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 13 (2017), 612-619
ISSN: 1860-5397

Factor impacto JCR: 2.33 (2017)
Categ. JCR: CHEMISTRY, ORGANIC rank: 25 / 57 = 0.439 (2017) - Q2 - T2
Factor impacto SCIMAGO: 0.929 - Organic Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/GAE-102
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)

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 Record created 2017-05-11, last modified 2019-07-09

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