Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients
Resumen: Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD.
Idioma: Inglés
Año: 2015
Publicado en: EXERCISE IMMUNOLOGY REVIEW 21 (2015), 80-112
ISSN: 1077-5552

Factor impacto JCR: 4.294 (2015)
Categ. JCR: SPORT SCIENCES rank: 5 / 81 = 0.062 (2015) - Q1 - T1
Categ. JCR: IMMUNOLOGY rank: 39 / 151 = 0.258 (2015) - Q2 - T1

Factor impacto SCIMAGO:

Tipo y forma: Article (Published version)
Área (Departamento): Educación Física y Deportiva (Departamento de Fisiatría y Enfermería)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


Exportado de SIDERAL (2017-05-18-10:32:52)

Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Educación Física y Deportiva



 Record created 2017-05-18, last modified 2017-05-18


Versión publicada:
 PDF
Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)