000061441 001__ 61441
000061441 005__ 20211117102002.0
000061441 0247_ $$2doi$$a10.1039/C6RA10058A
000061441 0248_ $$2sideral$$a96457
000061441 037__ $$aART-2016-96457
000061441 041__ $$aeng
000061441 100__ $$0(orcid)0000-0003-4891-105X$$aEncabo-Berzosa, M. Mar$$uUniversidad de Zaragoza
000061441 245__ $$aSelective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses
000061441 260__ $$c2016
000061441 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061441 5203_ $$aThe main challenge of cancer treatment is to avoid or minimize systemic side effects in off-target tissues. Mesenchymal stem cells (MSCs) can be used as therapeutical carriers because of their ability to migrate and incorporate into inflammation areas including tumors. Here, this homing ability is exploited by carrying therapeutic nanoparticles (Hollow Gold Nanoparticles (HGNs)) following a “Trojan-horse” strategy. Amongst the different nanoparticles to be employed, HGNs have the capacity to resonate in the near infrared region when irradiated by an appropriated laser (808 nm). By transforming this absorbed energy into heat, they are capable to produce locally induced hyperthermia. At this wavelength healthy tissues have a minimal light absorption being the effect restricted to the tissues containing HGNs. By placing HGNs inside MSCs, the recognition, excretion and immune response are minimized. We demonstrate that MSCs internalize HGNs and reach the tumors still containing HGNs. After laser treatment this loaded cells are able to eradicate tumoral cells in vitro and in vivo without significant toxicity. Also Ki67 expression, which is usually correlated with proliferation, is reduced after treatment. This approach enhances the effectiveness of the treatment when compared to just the enhanced permeation and retention effect (EPR) of the HGNs by themselves.
000061441 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000061441 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000061441 590__ $$a3.108$$b2016
000061441 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b59 / 166 = 0.355$$c2016$$dQ2$$eT2
000061441 592__ $$a0.889$$b2016
000061441 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1
000061441 593__ $$aChemical Engineering (miscellaneous)$$c2016$$dQ1
000061441 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000061441 700__ $$aGimeno, Marina
000061441 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluis$$uUniversidad de Zaragoza
000061441 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, María$$uUniversidad de Zaragoza
000061441 700__ $$aGómez, Leire
000061441 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000061441 700__ $$aQuintanilla, Miguel
000061441 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000061441 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000061441 700__ $$0(orcid)0000-0003-4160-9720$$aMartín-Duque, Pilar
000061441 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000061441 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000061441 773__ $$g6, 63 (2016), 58723-58732$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000061441 8564_ $$s2035117$$uhttps://zaguan.unizar.es/record/61441/files/texto_completo.pdf$$yPostprint
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000061441 951__ $$a2021-11-15-14:34:07
000061441 980__ $$aARTICLE