000061502 001__ 61502
000061502 005__ 20230210140617.0
000061502 0247_ $$2doi$$a10.1039/c6ra23620k
000061502 0248_ $$2sideral$$a98829
000061502 037__ $$aART-2016-98829
000061502 041__ $$aeng
000061502 100__ $$aEspañol, L.
000061502 245__ $$aDual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: Drug delivery and cytotoxicity assays
000061502 260__ $$c2016
000061502 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061502 5203_ $$aDual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis-encapsulation processes. This becomes even more difficult when the simultaneous encapsulation of molecules of different polarity is sought. Here we present a modified emulsification-evaporation process to produce polymeric nanoparticles (NPs) made of the biocompatible and biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) and co-encapsulating simultaneously two different drugs, the hydrophobic dexamethasone (DX) and the hydrophilic diclofenac sodium (DS). Three independent processing parameters were systematically modified to promote the incorporation of the different-polarity drugs into PLGA and to control the particle size under 150 nm. The careful selection of the appropriate solvents (ethyl acetate and methanol) was a key requirement for the successful encapsulation of DX and DS. DS and DX release kinetics as well as cytotoxicity assays underlined the therapeutic potential of the dual encapsulation strategy. © 2016 The Royal Society of Chemistry.
000061502 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM$$9info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO
000061502 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000061502 590__ $$a3.108$$b2016
000061502 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b59 / 166 = 0.355$$c2016$$dQ2$$eT2
000061502 592__ $$a0.889$$b2016
000061502 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1
000061502 593__ $$aChemical Engineering (miscellaneous)$$c2016$$dQ1
000061502 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061502 700__ $$0(orcid)0000-0002-6277-7996$$aLarrea, A.$$uUniversidad de Zaragoza
000061502 700__ $$aAndreu, V.
000061502 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, G.
000061502 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000061502 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000061502 700__ $$aAurora-Prado, M.S.
000061502 700__ $$aKedor-Hackmann, E.R.M.
000061502 700__ $$aSantoro, M.I.R.M.
000061502 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, J.$$uUniversidad de Zaragoza
000061502 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000061502 773__ $$g6, 112 (2016), 111060-111069$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000061502 8564_ $$s1580602$$uhttps://zaguan.unizar.es/record/61502/files/texto_completo.pdf$$yVersión publicada
000061502 8564_ $$s120405$$uhttps://zaguan.unizar.es/record/61502/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061502 909CO $$ooai:zaguan.unizar.es:61502$$particulos$$pdriver
000061502 951__ $$a2023-02-10-13:59:39
000061502 980__ $$aARTICLE