000061627 001__ 61627
000061627 005__ 20190709135428.0
000061627 0247_ $$2doi$$a10.1016/j.circir.2016.03.011
000061627 0248_ $$2sideral$$a99028
000061627 037__ $$aART-2017-99028
000061627 041__ $$aspa
000061627 100__ $$aEchazarreta-Gallego, E.
000061627 245__ $$aDevastadora complicación tras tratamiento con aflibercept
000061627 260__ $$c2017
000061627 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061627 5203_ $$aBackground The use of a new chemotherapy as adjuvant treatment of colorectal cancer is not free of complications. Monoclonal antibodies are associated with bleeding and intestinal perforations. Objective To report the case of a patient who developed a serious complication after treatment with an antiangiogenic drug for colorectal neoplasm. Clinical case The case is presented of a 42-year-old male operated on due to subocclusive rectal cancer with metástasis at the time of diagnosis. Sixteen months after surgery during second-line adjuvant therapy, an intestinal perforation was observed with haemorrhage and intestinal leak to retroperitoneum and left lower extremity. Despite intensive medical and surgical treatment this complication had fatal consequences. Conclusions Future research should be directed at obtaining biomarkers for the specific use of antiangiogenic agents in order to decrease the rate of adverse factors.
000061627 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000061627 590__ $$a0.427$$b2017
000061627 591__ $$aSURGERY$$b191 / 200 = 0.955$$c2017$$dQ4$$eT3
000061627 592__ $$a0.17$$b2017
000061627 593__ $$aSurgery$$c2017$$dQ4
000061627 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061627 700__ $$0(orcid)0000-0003-2671-061X$$aElía-Guedea, M.$$uUniversidad de Zaragoza
000061627 700__ $$aCórdoba-Díaz de Laspra, E.
000061627 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000061627 773__ $$g85, 3 (2017), 260-263$$pCirugia y Cirujanos$$tCirugia y Cirujanos$$x0009-7411
000061627 8564_ $$s785468$$uhttp://zaguan.unizar.es/record/61627/files/texto_completo.pdf$$yVersión publicada
000061627 8564_ $$s84463$$uhttp://zaguan.unizar.es/record/61627/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061627 909CO $$ooai:zaguan.unizar.es:61627$$particulos$$pdriver
000061627 951__ $$a2019-07-09-11:30:41
000061627 980__ $$aARTICLE