000061989 001__ 61989 000061989 005__ 20190709135434.0 000061989 0247_ $$2doi$$a10.1371/journal.pone.0180549 000061989 0248_ $$2sideral$$a100957 000061989 037__ $$aART-2017-100957 000061989 041__ $$aeng 000061989 100__ $$aAlcalde Cuesta, Fernando 000061989 245__ $$aSuppressors of selection 000061989 260__ $$c2017 000061989 5060_ $$aAccess copy available to the general public$$fUnrestricted 000061989 5203_ $$aInspired by recent works on evolutionary graph theory, an area of growing interest in mathematical and computational biology, we present examples of undirected structures acting as suppressors of selection for any fitness value r > 1. This means that the average fixation probability of an advantageous mutant or invader individual placed at some node is strictly less than that of this individual placed in a well-mixed population. This leads the way to study more robust structures less prone to invasion, contrary to what happens with the amplifiers of selection where the fixation probability is increased on average for advantageous invader individuals. A few families of amplifiers are known, although some effort was required to prove it. Here, we use computer aided techniques to find an exact analytical expression of the fixation probability for some graphs of small order (equal to 6, 8 and 10) proving that selection is effectively reduced for r > 1. Some numerical experiments using Monte Carlo methods are also performed for larger graphs and some variants. 000061989 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E15$$9info:eu-repo/grantAgreement/ES/MICINN/MTM2013-46337-C2-2-P$$9info:eu-repo/grantAgreement/ES/MICINN/MTM2016-77642-C2-2-P$$9info:eu-repo/grantAgreement/ES/UZ/CUD2015-10 000061989 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000061989 590__ $$a2.766$$b2017 000061989 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1 000061989 592__ $$a1.164$$b2017 000061989 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1 000061989 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1 000061989 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1 000061989 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000061989 700__ $$aGonzález Sequeiros, Pablo 000061989 700__ $$0(orcid)0000-0002-1184-5901$$aLozano Rojo, Álvaro 000061989 773__ $$g12, 7 (2017), [7 pp.]$$pPLoS One$$tPloS one$$x1932-6203 000061989 8564_ $$s428001$$uhttps://zaguan.unizar.es/record/61989/files/texto_completo.pdf$$yVersión publicada 000061989 8564_ $$s15856$$uhttps://zaguan.unizar.es/record/61989/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000061989 909CO $$ooai:zaguan.unizar.es:61989$$particulos$$pdriver 000061989 951__ $$a2019-07-09-11:33:09 000061989 980__ $$aARTICLE