000062018 001__ 62018 000062018 005__ 20190709135434.0 000062018 0247_ $$2doi$$a10.1371/journal.pone.0177289 000062018 0248_ $$2sideral$$a101082 000062018 037__ $$aART-2017-101082 000062018 041__ $$aeng 000062018 100__ $$aSoler, X. 000062018 245__ $$aAge, gender, neck circumference, and Epworth sleepiness scale do not predict obstructive sleep apnea (OSA) in moderate to severe chronic obstructive pulmonary disease (COPD): The challenge to predict OSA in advanced COPD 000062018 260__ $$c2017 000062018 5060_ $$aAccess copy available to the general public$$fUnrestricted 000062018 5203_ $$aThe combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is associated with substantial morbidity and mortality. We hypothesized that predictors of OSA among patients with COPD may be distinct from OSA in the general population. Therefore, we investigated associations between traditional OSA risk factors (e.g. age), and sleep questionnaires [e.g. Epworth Sleepiness Scale] in 44 patients with advanced COPD. As a second aim we proposed a pilot, simplified screening test for OSA in patients with COPD. In a prospective, observational study of patients enrolled in the UCSD Pulmonary Rehabilitation Program we collected baseline characteristics, cardiovascular events (e.g. atrial fibrillation), and sleep questionnaires [e.g. Pittsburgh Sleep Quality Index (PSQI)]. For the pilot questionnaire, a BMI =25 kg/m2 and the presence of cardiovascular disease were used to construct the pilot screening test. Male: 59%; OSA 66%. FEV1 (mean ± SD) = 41.0±18.2% pred., FEV1/FVC = 41.5±12.7%]. Male gender, older age, and large neck circumference were not associated with OSA. Also, Epworth Sleepiness Scale and the STOP-Bang questionnaire were not associated with OSA in univariate logistic regression. In contrast, BMI =25 kg/m2 (OR = 3.94, p = 0.04) and diagnosis of cardiovascular disease (OR = 5.06, p = 0.03) were significantly associated with OSA [area under curve (AUC) = 0.74]. The pilot COPD-OSA test (OR = 5.28, p = 0.05) and STOP-Bang questionnaire (OR = 5.13, p = 0.03) were both associated with OSA in Receiver Operating Characteristics (ROC) analysis. The COPD-OSA test had the best AUC (0.74), sensitivity (92%), and specificity (83%). A tenfold cross-validation validated our results. We found that traditional OSA predictors (e.g. gender, Epworth score) did not perform well in patients with more advanced COPD. Our pilot test may be an easy to implement instrument to screen for OSA. However, a larger validation study is necessary before further clinical implementation is warranted. 000062018 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000062018 590__ $$a2.766$$b2017 000062018 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1 000062018 592__ $$a1.164$$b2017 000062018 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1 000062018 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1 000062018 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1 000062018 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000062018 700__ $$aLiao, S.Y. 000062018 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza 000062018 700__ $$aLorenzi-Filho, G. 000062018 700__ $$aJen, R. 000062018 700__ $$aDeYoung, P. 000062018 700__ $$aOwens, R.L. 000062018 700__ $$aRies, A.L. 000062018 700__ $$aMalhotra, A. 000062018 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000062018 773__ $$g12, 5 (2017), 0177289 [12 pp]$$pPLoS One$$tPloS one$$x1932-6203 000062018 8564_ $$s531735$$uhttps://zaguan.unizar.es/record/62018/files/texto_completo.pdf$$yVersión publicada 000062018 8564_ $$s109825$$uhttps://zaguan.unizar.es/record/62018/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000062018 909CO $$ooai:zaguan.unizar.es:62018$$particulos$$pdriver 000062018 951__ $$a2019-07-09-11:33:27 000062018 980__ $$aARTICLE