000062048 001__ 62048 000062048 005__ 20210121114451.0 000062048 0247_ $$2doi$$a10.3305/nh.2015.32.5.9660 000062048 0248_ $$2sideral$$a92719 000062048 037__ $$aART-2015-92719 000062048 041__ $$aeng 000062048 100__ $$aBoj Carceller, D. 000062048 245__ $$aTreatment of subclinical hyperthyroidism: Effect on body composition 000062048 260__ $$c2015 000062048 5060_ $$aAccess copy available to the general public$$fUnrestricted 000062048 5203_ $$aBackground: subclinical hyperthyroidism (SHT) is associated with harmful effects on cardiovascular system, bone metabolism and progression to clinical hyperthyroidism. Loss of weight is a common fact in patients with clinical hyperthyroidism and of particular relevance in elderly patients. Objective: to assess changes in body composition after radioiodine therapy for SHT due to toxic nodular goiter. Subjects and methods: prospective controlled cohort study. Patients with persistent SHT due to toxic nodular goiter were purposed to receive treatment with radioiodine (treatment group) or to delay treatment until the study was over (control group). All treated patients received 555 MBq of 131I. Body composition (lean mass, fat mass and bone mineral content) was determined by dual-energy X-ray absorptiometry (DEXA) at baseline and 12 months after. Results: twenty-nine patients were studied (age 69.5 ± 11.5; 75.9% women; BMI 27.1 ± 5.7 kg/m²; serum thyrotropin (TSH) 0.20 ± 0.21 µUI/mL; serum free thyroxine (T4) 1.01 ± 0.19 ng/dL), 17 belonging to the treatment group and 12 to the control group. Study groups were comparable, although there was a trend for the treatment group to have more fat mass. No longitudinal changes in body composition were noted in either group, except for a trend to gain fat mass. However, when individuals with age > 65 years were selected, only patients who received radioiodine therapy showed a significant increase in body weight (from 64.1 ± 10.0 to 66.9 ± 9.2 kg), BMI (from 27.3 ± 4.8 to 28.7 ± 4.5 kg/m²), fat mass (from 26.1 ± 8.5 to 27.8 ± 7.9 kg), lean mass (from 36.3 ± 0.4 to 37.4 ± 0.4 kg) and skeletal muscle mass index (SMI) (from 6.0 ± 0.6 to 6.3 ± 0.6 kg/m²). Conclusions: treatment of SHT has impact on body composition in subjects older than 65 years. Weight gain reflects increases in fat and, more interestingly, in lean mass. 000062048 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000062048 590__ $$a1.497$$b2015 000062048 591__ $$aNUTRITION & DIETETICS$$b60 / 80 = 0.75$$c2015$$dQ3$$eT3 000062048 592__ $$a0.404$$b2015 000062048 593__ $$aNutrition and Dietetics$$c2015$$dQ3 000062048 593__ $$aMedicine (miscellaneous)$$c2015$$dQ3 000062048 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000062048 700__ $$0(orcid)0000-0002-7758-3588$$aSanz París, A..$$uUniversidad de Zaragoza 000062048 700__ $$0(orcid)0000-0001-9462-1008$$aSánchez Oriz, E.$$uUniversidad de Zaragoza 000062048 700__ $$0(orcid)0000-0002-0445-2958$$aGarcía-Foncillas López, R.$$uUniversidad de Zaragoza 000062048 700__ $$aCalmarza Calmarza, P. 000062048 700__ $$0(orcid)0000-0002-3144-4857$$aBlay Cortes, V.$$uUniversidad de Zaragoza 000062048 700__ $$0(orcid)0000-0002-5512-5885$$aAbós Olivares, M.D.$$uUniversidad de Zaragoza 000062048 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física 000062048 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000062048 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ. 000062048 773__ $$g32, 5 (2015), 2331-2337$$pNutr. hosp.$$tNutricion Hospitalaria$$x0212-1611 000062048 8564_ $$s372893$$uhttps://zaguan.unizar.es/record/62048/files/texto_completo.pdf$$yVersión publicada 000062048 8564_ $$s110583$$uhttps://zaguan.unizar.es/record/62048/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000062048 909CO $$ooai:zaguan.unizar.es:62048$$particulos$$pdriver 000062048 951__ $$a2021-01-21-10:46:11 000062048 980__ $$aARTICLE