000062106 001__ 62106
000062106 005__ 20200221144322.0
000062106 0248_ $$2sideral$$a101444
000062106 037__ $$aART-2016-101444
000062106 041__ $$aeng
000062106 100__ $$aRodríguez-Valle, Ana
000062106 245__ $$aThe effect of orlistat on postprandial hypertriglyceridemia by oral fat loading test. A systematic review
000062106 260__ $$c2016
000062106 5060_ $$aAccess copy available to the general public$$fUnrestricted
000062106 5203_ $$aOrlistat induces weight loss by blocking hydrolysis of triglyceride in the intestine, and has thereby been associated with favorable changes in postprandial triglycerides (ppTGL). Some epidemiological studies have identified ppTGL concentrations as a significant risk factor for cardiovascular disease. Oral fat loading test (OFLT) has been used for screening of elevated levels of ppTGL. The objective of the present systematic review is to present available data on the effects of orlistat on OFLT. We found 11 studies, seven of which studied the effect of a single dose of orlistat on OFLT in three healthy volunteers, one with obesity, two with type-2 diabetes and one with hyperlipidemic patients. The other four studied the effect of orlistat on OFLT, but after a previous period of time with daily treatment with orlistat: 1 healthy volunteer, 2 obese volunteers, and one patient with hyperlipidemia. Our systematic review suggests that orlistat can help to reduce postprandial hypertriglyceridemia in obese, dyslipemic and type-2 diabetic patients. Regarding free fatty acids, they could be reduced but not all the authors have found the same results. In relation to type-2 diabetic patients, we have found three studies with conflicting results on the immediate effect of orlistat on the postprandial GLP-1 response. In conclusion, orlistat can help to reduce postprandial plasmatic TGL, especially in patients with postprandial hypertriglyceridemia related to obesity, dyslipidemia or type-2 diabetes.
000062106 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000062106 590__ $$a0.747$$b2016
000062106 591__ $$aNUTRITION & DIETETICS$$b68 / 81 = 0.84$$c2016$$dQ4$$eT3
000062106 592__ $$a0.4$$b2016
000062106 593__ $$aNutrition and Dietetics$$c2016$$dQ3
000062106 593__ $$aMedicine (miscellaneous)$$c2016$$dQ3
000062106 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000062106 700__ $$aNavarro Ferrando, María Ángeles
000062106 700__ $$aBoj Carceller, Diana$$uUniversidad de Zaragoza
000062106 700__ $$aGonzález-Cantalejo, Mar
000062106 700__ $$0(orcid)0000-0002-6012-7412$$aEscanero Marcén, Jesús Fernando$$uUniversidad de Zaragoza
000062106 700__ $$0(orcid)0000-0002-7758-3588$$aSanz-Paris, Alejandro$$uUniversidad de Zaragoza
000062106 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000062106 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000062106 773__ $$g33, 2 (2016), 472-481$$pNutr. hosp.$$tNUTRICION HOSPITALARIA$$x0212-1611
000062106 85641 $$uhttp://scielo.isciii.es/pdf/nh/v33n2/45_revision2.pdf$$zTexto completo de la revista
000062106 8564_ $$s717657$$uhttps://zaguan.unizar.es/record/62106/files/texto_completo.pdf$$yVersión publicada
000062106 8564_ $$s78171$$uhttps://zaguan.unizar.es/record/62106/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000062106 909CO $$ooai:zaguan.unizar.es:62106$$particulos$$pdriver
000062106 951__ $$a2020-02-21-13:41:59
000062106 980__ $$aARTICLE