Shell cross-linked polymeric micelles as Camptothecin nanocarriers for anti-HCV therapy
Resumen: A suitable carrier for camptothecin to act as therapy against the hepatitis C virus is presented. The carrier relies on an amphiphilic hybrid dendritic–linear–dendritic block copolymer, derived from pluronic F127 and bis-MPA dendrons, that forms micelles in aqueous solution. The dendrons admit the incorporation of multiple photoreactive groups that allow the clean and effective preparation of covalently cross-linked polymeric micelles (CLPM), susceptible of loading hydrophilic and lipophilic molecules. Cell-uptake experiments using a newly designed fluorophore, derived from rhodamine B, demonstrate that the carrier favors the accumulation of its cargo within the cell. Furthermore, loaded with camptothecin, it is efficient in fighting against the hepatitis C virus while shows lower cytotoxicity than the free drug.
Idioma: Inglés
DOI: 10.1002/mabi.201500094
Año: 2015
Publicado en: MACROMOLECULAR BIOSCIENCE 15, 10 (2015), [36 pp.]
ISSN: 1616-5187

Factor impacto JCR: 3.68 (2015)
Categ. JCR: POLYMER SCIENCE rank: 11 / 85 = 0.129 (2015) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 90 / 289 = 0.311 (2015) - Q2 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 9 / 32 = 0.281 (2015) - Q2 - T1

Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/DGA/B01
Financiación: info:eu-repo/grantAgreement/ES/DGA/B054-12
Financiación: info:eu-repo/grantAgreement/ES/DGA/B136-13
Financiación: info:eu-repo/grantAgreement/ES/DGA/B89
Financiación: info:eu-repo/grantAgreement/ES/DGA/E04
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI10-00186
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CPII13-0017
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CP07-00289
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU12-05210
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU13-3870
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2012-35692
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2012-38538-C03-01
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)

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